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Tumor Biology

, Volume 36, Issue 11, pp 8625–8635 | Cite as

SOX 1, contrary to SOX 2, suppresses proliferation, migration, and invasion in human laryngeal squamous cell carcinoma by inhibiting the Wnt/β-catenin pathway

  • Ning Yang
  • Yan Wang
  • Lian Hui
  • Xiaotian Li
  • Xuejun Jiang
Research Article

Abstract

Sex-determining region Y (SRY)-box protein 1 (SOX 1) has been reported to have the inhibiting effects on various cancer cells; however, the expression and effect of SOX 1 on laryngeal squamous cell carcinoma (LSCC) have not been determined. Therefore, the aim of this study was to assess the anti-proliferation and metastatic effects of SOX 1 and its related mechanisms on LSCC. According to our present study, first, we found that overexpression of SOX 1 could significantly inhibit proliferation and promote apoptosis in Tu212 cells. Additionally, overexpression of SOX 1 suppressed the migration and invasion potential of Tu212 cells via regulating Wnt/β-catenin pathway. Finally, we demonstrated for the first time that overexpression of SOX 1 could downregulate the expression of SOX 2, and co-expression of SOX 1 and SOX 2 could reverse the anti-tumor effect of SOX 1. In conclusion, our studies suggested that SOX 1 suppressed cell growth and invasion in Tu212 cells by inhibiting Wnt/β-catenin pathway, and the anti-tumor effect of SOX 1 could be weakened by SOX 2, which may be a potential molecular basis for clinical treatment of LSCC.

Keywords

LSCC SOX 1 SOX 2 Apoptosis Metastasis Wnt/β-catenin 

Notes

Acknowledgments

This study was supported by a grant from the Natural Science Foundation of Liaoning Province (No.: 201202287).

Conflicts of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  • Ning Yang
    • 1
  • Yan Wang
    • 1
  • Lian Hui
    • 1
  • Xiaotian Li
    • 1
  • Xuejun Jiang
    • 1
  1. 1.Department of OtorhinolaryngologyThe First Affiliated Hospital of China Medical UniversityShenyangChina

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