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Tumor Biology

, Volume 36, Issue 5, pp 3159–3169 | Cite as

Highlights on mechanisms of drugs targeting MDSCs: providing a novel perspective on cancer treatment

  • Wei Pan
  • Qian Sun
  • Yang Wang
  • Jian Wang
  • Shui Cao
  • Xiubao Ren
Review

Abstract

The hallmark of tumor microenvironment is that it makes up of numerous immunomodulatory cells and factors which exert essential roles in immunoprotection and immunosuppression in addition to tumor cells. Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells reported to promote immunosuppression and angiogenesis and facilitate tumor metastasis and invasion. The wide scope of MDSCs functional activities make these cells promising targets for effective cancer treatments. In this review, we briefly discuss the origin, subpopulation, and functions of MDSCs, as well as the potential to target these cells for therapeutic benefit. We focus on the underlying molecular mechanisms of these drugs targeting MDSCs, mainly from the standpoint of molecules related to drug targets.

Keywords

MDSCs Mechanisms Tumor microenvironment Subpopulation Functional regulation Therapeutic implication 

Abbreviations

MDSCs

Myeloid-derived suppressor cells

NK

Natural killer

DCs

Dendritic cells

CTLs

Cytotoxic T lymphocytes

Tregs

Regulatory T lymphocytes

MMP

Matrix metallo proteinase

MCP-1

Monocyte chemoattractant protein 1

VEGP

Vascular endothelial growth factor

iNOS

inducible NO synthase

PDE5

Phosphodiesterase 5

HMGB1

High mobility group box 1

TGF-β

Transforming growth factor β

C/EBPβ

CCAAT/enhancer-binding protein β

IRF

Interferon regulatory factor

NF-κB

Nuclear factor κB

JAK

Janus kinase

STAT

Signal transducer and activator of transcription

IDO

Indoleamine 2,3-dioxygenase

G-CSF

Granulocyte colony-stimulating factor

COX2

Cyclooxygenase 2

BMP4

Bone morphogenetic protein 4

AATCs

Activated T cells (ATCs) armed with bispecific antibodies

CpG

The toll-like receptor (TLR) 9 ligand

Notes

Aknowledgments

This work was supported by the National Natural Science Foundation of China (No. 81472471). John E. Anderson, M.D. from Johns Hopkins University provided his personal assistance in the preparation of the work.

Conflicts of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  1. 1.Department of immunologyTianjin Medical University Cancer Institute and HospitalTianjinChina
  2. 2.Department of BiotherapyTianjin Medical University Cancer Institute and HospitalTianjinChina
  3. 3.Key Laboratory of Cancer Immunology and BiotherapyTianjinChina
  4. 4.National Clinical Research Center of CancerTianjinChina

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