Tumor Biology

, Volume 36, Issue 8, pp 6425–6431 | Cite as

Vitamin D receptor gene polymorphisms and breast cancer risk among postmenopausal Egyptian women

  • Eman Abd-Elkader Abd-Elsalam
  • Nadia A. Ismaeil
  • Hoda Sibai Abd-Alsalam
Research Article


Many studies reported that vitamin D can protect against various types of cancers. The mechanism of vitamin D action is mediated by the vitamin D receptor (VDR). VDR may have anti-stress function because it has been identified as p53 direct target gene. This research was designed to investigate the role of VDR polymorphisms BsmI (rs 1544410), ApaI (rs 7975232), TaqI (rs 731236), and FokI (rs 10735810) in pathogenesis of breast cancer using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. The study included 130 postmenopausal breast cancer cases aged 49 to 65 years and 100 controls aged 50 to 72 years. A significantly increased risk of breast cancer among carriers of BsmI bb genotype was observed (OR = 2.5 (1.1–5.6), P = 0.025). Also, a significantly increased risk of breast cancer was detected among women carrying ApaI aa genotype (OR = 2.2 (1.02–4.5), P = 0.04), while no significant associations were observed between breast cancer risk and genotypes and allele frequencies of FokI and TaqI polymorphisms (P > 0.05). Our study showed that VDR gene polymorphisms (BsmI and ApaI) may contribute to breast cancer risk among postmenopausal women.


VDR Breast cancer BsmI ApaI Polymorphism 



Vitamin D receptor


Single-nucleotide polymorphisms


polymerase chain reaction


Restriction fragment length polymorphism


Estrogen receptor


Progesterone receptor



Authors are deeply grateful to all volunteers and patients.

Conflict of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  • Eman Abd-Elkader Abd-Elsalam
    • 1
  • Nadia A. Ismaeil
    • 2
  • Hoda Sibai Abd-Alsalam
    • 3
  1. 1.Medical Biochemistry Department, Faculty of MedicineZagazig UniversityZagazigEgypt
  2. 2.General Surgery Department, Faculty of MedicineZagazig UniversityZagazigEgypt
  3. 3.Obstetrics and Gynecology Department, Faculty of MedicineZagazig UniversityZagazigEgypt

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