Tumor Biology

, Volume 36, Issue 8, pp 6401–6408 | Cite as

Long noncoding RNAs POLR2E rs3787016 C/T and HULC rs7763881 A/C polymorphisms are associated with decreased risk of esophageal cancer

  • Mingqiang Kang
  • Yonghua Sang
  • Haiyong Gu
  • Liang Zheng
  • Liming Wang
  • Chao Liu
  • Yijun Shi
  • Aizhong Shao
  • Guowen Ding
  • Suocheng Chen
  • Weifeng Tang
  • Jun Yin
Research Article

Abstract

Worldwide, rates of esophageal cancer have been keeping highly in recent decades. Genetic variants in multiple cellular pathways might play an important role in altering risk of esophageal carcinoma. In this study, long noncoding RNAs (lncRNAs) functional single nucleotide polymorphisms (SNPs) were investigated in Chinese Han populations. We have genotyped the ANRIL rs2151280 T/C, POLR2E rs3787016 C/T, and HULC rs7763881 A/C SNPs in 380 esophageal squamous cell carcinoma (ESCC) cases and 380 cancer-free controls. POLR2E rs3787016 C/T was associated with a significantly decreased risk for ESCC (CT vs. CC: OR 0.62, 95 % CI 0.44–0.87, P = 0.005; adjusted OR 0.62, 95 % CI 0.44–0.87, P = 0.005). The other SNP, HULC rs7763881, also showed a suggestive association (AC vs. AA: OR 0.70, 95 % CI 0.50–0.98, P = 0.037; adjusted OR 0.69, 95 % CI 0.49–0.97, P = 0.031). ANRIL rs2151280 T/C SNP was not associated with risk of ESCC. In the future, larger studies with other ethnic populations, tissue-specific biological characterization, and detailed individual information should be undertaken to validate current findings.

Keywords

lncRNAs Polymorphisms Esophageal cancer Molecular epidemiology 

Abbreviations

lncRNAs

Long noncoding RNAs

LD

Linkage disequilibrium

OR

Odds ratio

CI

Confidential interval

SNPs

Single nucleotide polymorphisms

ESCC

Esophageal squamous cell carcinoma

Notes

Acknowledgments

We appreciate all patients who participated in this study. This study was supported in part by the National Natural Science Foundation of China (81472332, 81370001, 81300037, 81101889, 81000028, 81341006), Jiangsu Province Natural Science Foundation (BK2010333, BK2011481), Fujian Province Natural Science Foundation (2013J01126, 2013J05116), Fujian Medical University professor fund (JS12008) and Fujian Province science and technology programmed fund (2012Y0030), Social Development Foundation of Zhenjiang (SH2010017), and Changzhou Young Talents and Science-Technology Foundation of Health Bureau (QN201102).

Conflicts of interest

None

Supplementary material

13277_2015_3328_MOESM1_ESM.docx (29 kb)
Table S1 (DOCX 29 kb)

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  • Mingqiang Kang
    • 1
  • Yonghua Sang
    • 2
  • Haiyong Gu
    • 3
  • Liang Zheng
    • 4
  • Liming Wang
    • 5
  • Chao Liu
    • 3
  • Yijun Shi
    • 3
  • Aizhong Shao
    • 3
  • Guowen Ding
    • 3
  • Suocheng Chen
    • 3
  • Weifeng Tang
    • 3
  • Jun Yin
    • 3
    • 6
  1. 1.Department of Thoracic Surgery, Affiliated Union HospitalFujian Medical UniversityFuzhouChina
  2. 2.Department of Cardiothoracic SurgeryThe Second Affiliated Hospital of Soochow UniversitySuzhouChina
  3. 3.Department of Cardiothoracic SurgeryAffiliated People’s Hospital of Jiangsu UniversityZhenjiangChina
  4. 4.Department of Cardiothoracic SurgeryThe First People’s Hospital of Changzhou and The Third Affiliated Hospital of Suzhou UniversityChangzhouChina
  5. 5.Cancer Institute, Department of ChemotherapyPeople’s Hospital Affiliated to Jiangsu UniversityZhenjiangChina
  6. 6.Department of Cardiothoracic SurgeryAffiliated People’s Hospital of Jiangsu UniversityZhenjiangChina

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