Tumor Biology

, Volume 36, Issue 8, pp 6375–6382 | Cite as

Clinicopathological features of gastric adenocarcinoma patients with metachronous distant metastasis

  • Junjie Bao
  • Guofan Qu
  • Wangshu Fu
  • Yanjing Li
  • Haibin Song
  • Yuzhe Wei
  • Yingwei Xue
Research Article
  • 109 Downloads

Abstract

Metachronous distant metastasis influences the postoperative survival of gastric adenocarcinoma patients with radical gastrectomy. We retrospectively reviewed 108 gastric adenocarcinoma patients with metachronous distant metastasis admitted to our hospital between January 2006 and December 2011. First, these patients were divided into two groups according to the time of metastasis: the early metastasis group (EMG) and late metastasis group (LMG). Second, according to the survival time after metastasis, these patients were divided into the longer survival group (LSG) and shorter survival group (SSG). Chi-square and Fisher exact tests were used to analyze associations between categorical variables. Survival data were estimated using the Kaplan–Meier method. Multivariate analyses of the prognostic factors related to overall survival were conducted using the Cox stepwise proportional hazards test. Results shows that the EMG was significantly associated with depth of invasion (p = 0.005), Union for International Cancer Control (UICC) stage (p = 0.003), degree of differentiation (p = 0.002), and vascular invasion (p = 0.001). The SSG was significantly associated with depth of invasion (p = 0.026) and normal carcinoembryonic antigen (CEA) level of after metastasis (p = 0.003). Survival analysis showed that depth of invasion (p < 0.001), degree of differentiation (p = 0.001), and vascular invasion (p = 0.011) were independent prognostic factors for gastric adenocarcinoma patients with metachronous distant metastasis. Gastric adenocarcinoma patients with metachronous distant metastasis exhibit characteristics that can be used to effectively estimate the possibility of early distant metastasis and the prognosis of these patients.

Keywords

Gastric adenocarcinoma Metachronous distant metastasis Clinicopathological features 

Notes

Acknowledgments

This study was supported by a grant from The Third Affiliated Hospital of Harbin Medical University. The authors thank Yang Gao, Shanshan Sun, and Rui Xie for excellent assistances.

References

  1. 1.
    Siegel R, Ma J, Zou Z, Jemal A. Cancer statistics, 2014. CA Cancer J Clin. 2014;64(1):9–29.CrossRefPubMedGoogle Scholar
  2. 2.
    Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 2010;127(12):2893–917.CrossRefPubMedGoogle Scholar
  3. 3.
    Chen W, Zheng R, Zhang S, Zhao P, Zeng H, Zou X, et al. Annual report on status of cancer in China. Chin J Cancer Res Chung-kuo Yen Cheng Yen Chiu 2014. 2010;26(1):48–58.Google Scholar
  4. 4.
    Peng Z, Xu S, Li H, Sun C, Fu M, Gao M. Advanced gastric cancer with brain metastasis effectively treated by arterial infusion chemotherapy: a case report. Oncol Lett. 2014;7(2):449–51.PubMedGoogle Scholar
  5. 5.
    Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011;61(2):69–90.CrossRefPubMedGoogle Scholar
  6. 6.
    Choi SB, Song J, Kang CM, Hyung WJ, Kim KS, Choi JS, et al. Surgical outcome of metachronous hepatic metastases secondary to gastric cancer. Hepato-Gastroenterology. 2010;57(97):29–34.PubMedGoogle Scholar
  7. 7.
    Gupta GP, Massague J. Cancer metastasis: building a framework. Cell. 2006;127(4):679–95.CrossRefPubMedGoogle Scholar
  8. 8.
    Zhao X, Dou W, He L, Liang S, Tie J, Liu C, et al. MicroRNA-7 functions as an anti-metastatic microRNA in gastric cancer by targeting insulin-like growth factor-1 receptor. Oncogene. 2013;32(11):1363–72.CrossRefPubMedGoogle Scholar
  9. 9.
    Zheng J, Yu S, Qiao Y, Zhang H, Liang S, Wang H, et al. LASP-1 promotes tumor proliferation and metastasis and is an independent unfavorable prognostic factor in gastric cancer. J Cancer Res Clin Oncol. 2014;140(11):1891–9.CrossRefPubMedGoogle Scholar
  10. 10.
    Yang D, Hendifar A, Lenz C, Togawa K, Lenz F, Lurje G, et al. Survival of metastatic gastric cancer: significance of age, sex and race/ethnicity. J Gastrointest Oncol. 2011;2(2):77–84.PubMedPubMedCentralGoogle Scholar
  11. 11.
    Ru GQ, Wang HJ, Xu WJ, Zhao ZS. Upregulation of twist in gastric carcinoma associated with tumor invasion and poor prognosis. Pathol Oncol Res: POR. 2011;17(2):341–7.CrossRefPubMedGoogle Scholar
  12. 12.
    Song Y, Zhao F, Wang Z, Liu Z, Chiang Y, Xu Y, et al. Inverse association between miR-194 expression and tumor invasion in gastric cancer. Ann Surg Oncol. 2012;19 Suppl 3:S509–17.CrossRefPubMedGoogle Scholar
  13. 13.
    Maas MC, Schaart DR, van der Laan DJ, Bruyndonckx P, Lemaitre C, Beekman FJ, et al. Monolithic scintillator PET detectors with intrinsic depth-of-interaction correction. Phys Med Biol. 2009;54(7):1893–908.CrossRefPubMedGoogle Scholar
  14. 14.
    Giaginis C, Efkarpidis T, Alexandrou P, Patsouris E, Kouraklis G, Theocharis S. Increased RCAS1 expression is associated with advanced histopathological stage and poor prognosis in patients with gastric adenocarcinoma. Dis Markers. 2013;35(4):213–9.CrossRefPubMedPubMedCentralGoogle Scholar
  15. 15.
    Guo J, Xiao JJ, Zhang X, Fan KX. CD40 expression and its prognostic significance in human gastric carcinoma. Med Oncol. 2015;32(3):463.Google Scholar
  16. 16.
    Liu Z, Shao Y, Tan L, Shi H, Chen S, Guo J. Clinical significance of the low expression of FER1L4 in gastric cancer patients. Tumour Biol: J Int Soc Oncodevelopmental Biol Med. 2014;35(10):9613–7.CrossRefGoogle Scholar
  17. 17.
    Chen J, Li T, Liu Q, Jiao H, Yang W, Liu X, et al. Clinical and prognostic significance of HIF-1alpha, PTEN, CD44v6, and survivin for gastric cancer: a meta-analysis. PLoS One. 2014;9(3):e91842.CrossRefPubMedPubMedCentralGoogle Scholar
  18. 18.
    Katada T, Ishiguro H, Kuwabara Y, Kimura M, Mitui A, Mori Y, et al. MicroRNA expression profile in undifferentiated gastric cancer. Int J Oncol. 2009;34(2):537–42.PubMedGoogle Scholar
  19. 19.
    Adachi Y, Yasuda K, Inomata M, Sato K, Shiraishi N, Kitano S. Pathology and prognosis of gastric carcinoma: well versus poorly differentiated type. Cancer. 2000;89(7):1418–24.CrossRefPubMedGoogle Scholar
  20. 20.
    Turkoz FP, Solak M, Kilickap S, Ulas A, Esbah O, Oksuzoglu B, et al. Bone metastasis from gastric cancer: the incidence, clinicopathological features, and influence on survival. J Gastric Cancer. 2014;14(3):164–72.CrossRefPubMedPubMedCentralGoogle Scholar
  21. 21.
    Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144(5):646–74.CrossRefPubMedGoogle Scholar
  22. 22.
    Chen J, Wang J, Lin L, He L, Wu Y, Zhang L, et al. Inhibition of STAT3 signaling pathway by nitidine chloride suppressed the angiogenesis and growth of human gastric cancer. Mol Cancer Ther. 2012;11(2):277–87.CrossRefPubMedGoogle Scholar
  23. 23.
    Fang CL, Hseu YC, Lin YF, Hung ST, Tai C, Uen YH, et al. Clinical and prognostic association of transcription factor SOX4 in gastric cancer. PLoS One. 2012;7(12):e52804.CrossRefPubMedPubMedCentralGoogle Scholar
  24. 24.
    Xing X, Lian S, Hu Y, Li Z, Zhang L, Wen X, et al. Phosphatase of regenerating liver-3 (PRL-3) is associated with metastasis and poor prognosis in gastric carcinoma. J Transl Med. 2013;11:309.CrossRefPubMedPubMedCentralGoogle Scholar
  25. 25.
    Martin 2nd RC, Jaques DP, Brennan MF, Karpeh M. Extended local resection for advanced gastric cancer: increased survival versus increased morbidity. Ann Surg. 2002;236(2):159–65.CrossRefPubMedPubMedCentralGoogle Scholar
  26. 26.
    Konstadoulakis MM, Syrigos KN, Albanopoulos C, Mayers G, Golematis B. The presence of anti-carcinoembryonic antigen (CEA) antibodies in the sera of patients with gastrointestinal malignancies. J Clin Immunol. 1994;14(5):310–3.CrossRefPubMedGoogle Scholar
  27. 27.
    Shirasu N, Yamada H, Shibaguchi H, Kuroki M, Kuroki M. Potent and specific antitumor effect of CEA-targeted photoimmunotherapy. Int J Cancer. 2014;135(11):2697–710.CrossRefPubMedGoogle Scholar

Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  • Junjie Bao
    • 1
  • Guofan Qu
    • 2
  • Wangshu Fu
    • 3
  • Yanjing Li
    • 4
  • Haibin Song
    • 1
  • Yuzhe Wei
    • 1
  • Yingwei Xue
    • 1
  1. 1.Department of Gastroenterologic SurgeryHarbin Medical University Cancer HospitalHarbinChina
  2. 2.Department of Orthopedics DepartmentHarbin Medical University Cancer HospitalHarbinChina
  3. 3.Department of PharmacyThe First Clinical Medical College of Harbin Medical UniversityHarbinChina
  4. 4.Department of Gastrointestinal OncologyHarbin Medical University Cancer HospitalHarbinChina

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