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Tumor Biology

, Volume 36, Issue 8, pp 6249–6254 | Cite as

Correlation of microRNA-10b upregulation and poor prognosis in human gliomas

Research Article

Abstract

The aim of this study was to detect the association between the microRNA-10b (miR-10b) expression level and prognosis in glioma patients. Quantitative real-time polymerase chain reaction (qRT-PCR) analysis was used to measure the expression of miR-10b levels in different-grade glioma tissues and normal brain tissues. The relationship between miR-10b expression levels and clinical pathological characteristics was statistically analyzed. The influence of miR-10b on survival of glioma patients was also analyzed. As a result, miR-10b expression levels in glioma tissues were significantly increased compared to those of normal brain tissues (p < 0.001). And the increased expression levels were associated with the advanced glioma grade (p < 0.001) and larger tumor size (p < 0.001). Moreover, the results of the Kaplan–Meier survival curve indicated that overall survival (OS) and progression-free survival (PFS) were significantly poorer in the high-expression-level group than those in the low-expression-level group (p < 0.001). Finally, the results of the multivariate Cox regression model indicated that the miR-10b expression level was an independent prognostic factor for glioma patients. Taken together, these findings offer convincing evidence that increased miR-10b expression may be an independent marker to predict poor prognosis in patients with gliomas.

Keywords

Glioma MicroRNA-10b Overall survival Progression-free survival 

Notes

Conflicts of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  1. 1.Medical CenterTsinghua UniversityBeijingChina
  2. 2.Department of Neurosurgery, Yuquan HospitalTsinghua UniversityBeijingChina
  3. 3.School of MedicineInner Mongolia University for the NationalitiesTongliaoChina

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