Tumor Biology

, Volume 36, Issue 8, pp 5971–5977 | Cite as

Combined effects of anticancer drugs and new synthetic α-methylene-δ-lactones on MCF-7 cells

  • Katarzyna Gach
  • Jacek Szymański
  • Dorota Pomorska
  • Angelika Długosz
  • Jakub Modranka
  • Tomasz Janecki
  • Anna Janecka
Research Article

Abstract

The search for novel drug candidates is a priority goal for cancer therapy. Natural products isolated from plants are often used as valuable leads for the synthesis of analogs with simpler structure. Two synthetic α-methylene-δ-lactones with chroman-2-one skeleton, designated DL-3 and DL-5, exhibiting strong cytotoxic activity against several cancer cell lines, have been tested alone and in combination with well-known anticancer drugs, 5-fluorouracil, oxaliplatin, and taxol, in breast cancer MCF-7 cells. Parthenolide, a plant-derived α-methylene-γ-lactone, was used as a positive control. The effects on cell proliferation, DNA damage, and apoptosis induction were evaluated. Neither of the tested compounds significantly enhanced the effects produced by taxol, but a strong synergistic effect was observed with 5-fluorouracil and oxaliplatin. Only small differences between the actions of both α-methylene-δ-lactones were found. The synergistic effects produced by these compounds in MCF-7 cells were stronger as compared with parthenolide. Our findings show that simple and easy-to-obtain synthetic compounds with α-methylene-δ-lactone motif can potentiate the efficiency of anticancer drugs.

Keywords

Anticancer drugs Apoptosis Breast cancer Cell proliferation DNA damage α-Methylene-δ-lactones 

Notes

Acknowledgments

This work was financed by the Medical University of Lodz (No. 502-14-191 to KG and No. 503/1-156-02/503-01) and by the Ministry of Science and Higher Education (Project No. N N204 005736).

Conflicts of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  • Katarzyna Gach
    • 1
  • Jacek Szymański
    • 2
  • Dorota Pomorska
    • 1
  • Angelika Długosz
    • 1
  • Jakub Modranka
    • 3
  • Tomasz Janecki
    • 3
  • Anna Janecka
    • 1
  1. 1.Department of Biomolecular Chemistry, Faculty of MedicineMedical University of LodzLodzPoland
  2. 2.Central Scientific Laboratory, Division of Public Health, Faculty of Health SciencesMedical University of LodzLodzPoland
  3. 3.Institute of Organic ChemistryLodz University of TechnologyLodzPoland

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