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Tumor Biology

, Volume 36, Issue 7, pp 5341–5351 | Cite as

SUZ12 promotes gastric cancer cell proliferation and metastasis by regulating KLF2 and E-cadherin

Research Article

Abstract

SUZ12 is a core component of the polycomb repressive complex 2 (PRC2), which could silence gene transcription by generating trimethylation on lysine 27 residue of histone H3 (H3K27Me3). Meanwhile, SUZ12 has been found to be overexpressed in multiple cancers; however, the clinical significance and molecular mechanisms of SUZ12 controlling gastric cancer cell proliferation and metastasis are unclear. In this study, we found that SUZ12 expression was significantly increased in 64 gastric tumor tissues compared with normal tissues. Additionally, SUZ12 expression was associated with pathological stage, metastasis distance, and shorter overall survival of gastric cancer patients. Knockdown of SUZ12 expression impaired cell proliferation and invasion in vitro, leading to the inhibition of metastasis in vivo. Upregulation of SUZ12 was found to play a key role in gastric cancer cell proliferation and metastasis through the regulation of EMT and KLF2 expression.

Keywords

Gastric cancer SUZ12 Metastasis EMT KLF2 

Notes

Acknowledgments

This work was supported by grants from the National Natural Science Foundation of China (No. 81472198), the Key Clinical Medicine Technology Foundation of Jiangsu Province (No. BL2014096), and the Medical Key Talented Person Foundation of the Jiangsu Provincial Developing Health Project (No. RC2011080) to WZX

Conflicts of interest

None.

Supplementary material

13277_2015_3195_MOESM1_ESM.xls (10 kb)
ESM 1 (XLS 9 kb)

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  1. 1.Department of Biochemistry and Molecular BiologyNanjing Medical UniversityNanjingChina
  2. 2.Department of General SurgeryThe Second Hospital of Liuanyung and Clinical Cancer Institute of LianyungangLianyungangChina
  3. 3.Department of Oncology, Second Affiliated HospitalNanjing Medical UniversityNanjingChina
  4. 4.Department of Oncology, First Affiliated HospitalNanjing Medical UniversityNanjingChina

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