Tumor Biology

, Volume 36, Issue 2, pp 533–541 | Cite as

Krüppel-like factors in hepatocellular carcinoma

  • Xiao-Jie Lu
  • Yan Shi
  • Jin-Lian Chen
  • Shijie Ma


Hepatocellular carcinoma (HCC) is a disease with a high incidence and mortality rate worldwide. However, the mechanisms underlying its pathogenesis are still elusive. In recent years, studies on functions of Krüppel-like factors (KLFs) in HCC have shed new light on this field. To date, five members (KLF4, KLF6, KLF8, KLF9, and KLF17) in the KLF family have been reported to function in the pathogenesis of HCC in multiple ways, which hold the potential of deepening and widening our understanding in the initiation and progression of HCC. In this review, we focus on the functions, roles, and regulatory networks of these five KLFs in HCC, summarize key pathways, and propose areas for further investigation, with the hope that this review will provide a reliable and concise reference for readers interested in this area.


Hepatocellular carcinoma Krüppel-like factor Tumor suppressor gene Oncogene 



National High Technology Research (863) Project of China (2012AA020204).

Conflicts of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  1. 1.Department of Gastroenterology, Shanghai East HospitalTongji University School of MedicineShanghaiChina
  2. 2.Department of EmergencyThe Affiliated Huai’an Hospital of Xuzhou Medical College and The Second People’s Hospital of Huai’anHuai’anChina
  3. 3.Department of Gastroenterology, Shanghai Sixth People’s Hospital (South)Shanghai Jiaotong University School of MedicineShanghaiChina
  4. 4.Department of Gastroenterology, Huai’an First People’s HospitalNanjing Medical UniversityHuai’anChina

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