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Tumor Biology

, Volume 36, Issue 6, pp 4633–4642 | Cite as

SYF2 is upregulated in human epithelial ovarian cancer and promotes cell proliferation

  • Sujuan Yan
  • Yan Deng
  • Yong Qiang
  • Qinghua Xi
  • Rong Liu
  • Shuyun Yang
  • Jian Liu
  • Chunhui Tang
  • Jianxin Zhong
  • Yingying Wang
Research Article

Abstract

SYF2 is reported to be as a cell cycle regulator at the G1/S transition and encodes a nuclear protein that interacts with cyclin-D-type binding protein 1. In our study, we investigated the role of SYF2 in human epithelial ovarian cancer (EOC) progression. Western blot and immunohistochemistry analysis displayed that SYF2 was overexpressed in EOC tissues and EOC cell lines. In addition, the immunoreactivity of SYF2 was positively correlated with tumor grade and Ki-67 expression. In vitro, serum starvation-refeeding experiment and SYF2-siRNA transfection assay demonstrated that the expression of SYF2 was promoted in the proliferative progression of EOC cells, while knockdown of SYF2 expression decreased and inhibited cell growth rate of EOC cells. With all the results, we support that SYF2 might contribute to EOC progression via modulation of proliferation in EOC cells and would provide a novel therapeutic target of human EOC.

Keywords

Epithelial ovarian cancer (EOC) SYF2 Proliferation Prognosis 

Notes

Acknowledgments

This work was supported by the National Natural Science Foundation of China (No. 81302285).

Conflict of interest

None.

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  • Sujuan Yan
    • 1
    • 3
  • Yan Deng
    • 2
  • Yong Qiang
    • 4
  • Qinghua Xi
    • 2
  • Rong Liu
    • 5
  • Shuyun Yang
    • 6
  • Jian Liu
    • 2
  • Chunhui Tang
    • 2
  • Jianxin Zhong
    • 2
  • Yingying Wang
    • 1
  1. 1.Department of Pathogen Biology, Medical College, Jiangsu Provice Key Laboratory for Information and Molecular Drug TargetNantong UniversityNantongChina
  2. 2.Department of Obstetrics and Gynecology, Affiliated Hospital of Nantong UniversityNantong UniversityNantongChina
  3. 3.Department of Obstetrics and GynecologyThe First People’s Hospital of JingmenJingmenChina
  4. 4.Department of General SurgeryThe First People’s Hospital of JingmenJingmenChina
  5. 5.Department of Oncology, Nantong University Cancer HospitalNantong UniversityNantongChina
  6. 6.Department of Pathology, Nantong University Cancer HospitalNantong UniversityNantongChina

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