Tumor Biology

, Volume 36, Issue 6, pp 4397–4403 | Cite as

Prognostic value of soluble H7-B4 in pleural effusion associated with lung cancer

  • Chun-Hua Xu
  • Lan Cao
  • Xiu-Wei Zhang
  • Jun Yan
  • Li-Ke Yu
Research Article


B7-H4, a member of the inhibitory B7 family, can restrain T cell proliferation, activation, and cytokine secretion and may be involved in immune evasion in cancer patients. This study aimed to evaluate the diagnostic and prognostic value of pleural effusion levels of soluble B7-H4 (sB7-H4) in lung cancer patients with malignant pleural effusion (MPE). Pleural effusion samples were collected from 98 lung cancer patients with malignant effusion and from 60 patients with nonmalignant pleural effusion. Pleural effusion concentrations of sB7-H4 were measured using sandwich enzyme-linked immunosorbent assay. Malignant effusion exhibited higher sB7-H4 levels than those in nonmalignant effusion (P < 0.01). Lung cancer patients with pleural effusion sB7-H4 levels below 35.8 ng/ml had a longer overall survival than those with higher levels (P < 0.05). By multivariate analysis, pleural effusion sB7-H4 was an independent prognostic factor in patients with MPE. In conclusion, measurement of sB7-H4 might be a useful diagnostic and prognostic value for MPE patients.


Soluble B7-H4 Diagnosis Prognosis Lung cancer Pleural effusion 


Conflicts of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  • Chun-Hua Xu
    • 1
    • 2
  • Lan Cao
    • 2
  • Xiu-Wei Zhang
    • 3
  • Jun Yan
    • 4
  • Li-Ke Yu
    • 1
    • 2
  1. 1.Department of Respiratory MedicineNanjing Chest HospitalNanjingChina
  2. 2.Clinical Center of Nanjing Respiratory Diseases and ImagingNanjingChina
  3. 3.Department of Respiratory MedicineNanjing Jiangning HospitalNanjingChina
  4. 4.MOE Key Laboratory, Model Animal Research CenterNanjing UniversityNanjingChina

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