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Tumor Biology

, Volume 36, Issue 6, pp 4387–4396 | Cite as

Association between ADH1B and ADH1C polymorphisms and the risk of head and neck squamous cell carcinoma

  • Yong Bae Ji
  • Seung Hwan Lee
  • Kyung Rae Kim
  • Chul Won Park
  • Chang Myeon Song
  • Byung Lae Park
  • Hyoung Doo Shin
  • Kyung Tae
Research Article

Abstract

Alcohol consumption is one of the major risk factors for head and neck squamous cell carcinoma (HNSCC), and the alcohol dehydrogenase (ADH) family proteins are key enzymes in ethanol metabolism. We examined the associations between single nucleotide polymorphisms (SNPs) of ADH1B and ADH1C and the risk of HNSCC. We analyzed six SNPS of ADH1B, namely −992C > G, −957C > A, +3170A>G, +3377G>T, +3491G>A, and +13543A>G, and five SNPs of ADH1C, namely −1064C>T, −325G>C, +5702A>G, +7462T>C, and +13044A>G, in 260 Korean HNSCC patients and 330 controls, using single base extension and the TaqMan assay. The odds ratios (ORs) and 95 % confidence intervals (95 % CIs) of the CG and GG genotypes of ADH1B −992C>G, the AA genotype of −957C>A, the GG genotype of +3170A>G, the GA genotype of +3491G>A, and +13543A>G were 0.51 (0.32–0.82), 0.63 (0.42–0.94), 1.84 (1.13–2.99), 1.77 (1.15–2.73), 2.34 (1.44–3.79), and 2.21 (1.23–3.95), respectively. The ORs of ADH1C +13044A>G were 1.94 (1.01–3.71) and 1.97 (1.05–3.71) in the dominant and co-dominant models, respectively. The ORs of the GC genotype of ADH1C −325G>C and the AG genotype of +5702A>G were 2.52 (1.51–4.21) and 2.43 (1.36–4.32), respectively. ADH1B +3170A>G and ADH1C +13044A>G were in strong linkage disequilibrium with the other SNPs of ADH1B and ADH1C, respectively. There were gene-environment interactions between ADH1B +3170A>G and ADH1C +13044A>G and alcohol consumption and smoking. ADH1B +3170A>G and ADH1C +13044A>G SNPs are associated with an increased risk of HNSCC, and they could be used as biomarkers for the high-risk group of HNSCC in Koreans.

Keywords

Polymorphism SNP ADH1B ADH1C Head and neck cancer 

Notes

Conflicts of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  • Yong Bae Ji
    • 1
  • Seung Hwan Lee
    • 1
  • Kyung Rae Kim
    • 1
  • Chul Won Park
    • 1
  • Chang Myeon Song
    • 1
  • Byung Lae Park
    • 2
  • Hyoung Doo Shin
    • 2
  • Kyung Tae
    • 1
  1. 1.Department of Otolaryngology-Head and Neck Surgery, College of MedicineHanyang UniversitySeoulSouth Korea
  2. 2.Department of Genetic EpidemiologySNP Genetics, Inc.SeoulSouth Korea

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