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Tumor Biology

, Volume 36, Issue 6, pp 4107–4114 | Cite as

Kindlin-2 inhibited the growth and migration of colorectal cancer cells

  • Yuanyuan Ren
  • Hongsong Jin
  • Zhidong Xue
  • Qianlang Xu
  • Songhua Wang
  • Guojun Zhao
  • Junxing Huang
  • He Huang
Research Article

Abstract

Activation of Wingless (Wnt)/beta-catenin signaling is a hallmark of colorectal carcinoma (CRC). It is very important to find out the molecular mechanism for the hyperactivation of Wnt/beta-catenin signaling and identify novel therapeutic targets. Kindlin-2, a regulator of integrins, recently has been found to be involved in the tumorigenesis. However, its expression profile and functions in the progression of CRC remain poorly understood. Here, we found that the expression of Kindlin-2 was downregulated in the CRC tissues. Moreover, overexpression of Kindlin-2 in CRC cells and normal colon epithelial cells inhibited cell proliferation and migration, while downregulation of Kindlin-2 promoted the tumorigenecity of CRC cells in vitro and in vivo. Mechanistically, Kindlin-2 decreased the phosphorylation of Ser9 in glycogen synthase kinase (GSK) 3beta and promoted the ubiquitination of beta-catenin. Taken together, our study suggests the suppressive roles of Kindlin-2 in the pathogenesis of CRC.

Keywords

CRC Kindlin-2 Beta-catenin Cell proliferation and migration 

Notes

Conflicts of Interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  • Yuanyuan Ren
    • 1
  • Hongsong Jin
    • 1
  • Zhidong Xue
    • 1
  • Qianlang Xu
    • 1
  • Songhua Wang
    • 1
  • Guojun Zhao
    • 2
  • Junxing Huang
    • 3
  • He Huang
    • 3
  1. 1.Department of OncologyThe People’s Hospital of TaizhouTaizhouChina
  2. 2.Department of PathologyThe People’s Hospital of TaizhouTaizhouChina
  3. 3.The Institute of Cancer ResearchTaizhouChina

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