Tumor Biology

, Volume 36, Issue 5, pp 3931–3939 | Cite as

Genetic variations in monocarboxylate transporter genes as predictors of clinical outcomes in non-small cell lung cancer

  • Xu Guo
  • Cheng Chen
  • Boya Liu
  • Yousheng Wu
  • Yibing Chen
  • Xingchun Zhou
  • Xiaojun Huang
  • Xiaofei Li
  • Hushan Yang
  • Zhinan Chen
  • Jinliang Xing
Research Article

Abstract

Non-small cell lung cancer (NSCLC) is characterized by poor prognosis and only a few molecular markers may be potentially used to predict clinical outcomes. Previous studies have demonstrated that monocarboxylate transporters (MCTs) play important roles in the development and progression of many cancers. The purpose of this study was to assess the effects of single nucleotide polymorphisms (SNPs) of MCT genes on prognosis of NSCLC patients in Chinese Han population. Nine functional SNPs in MCT1, MCT2, and MCT4 genes were selected and genotyped using Sequenom iPLEX genotyping system in 500 Chinese NSCLC patients receiving surgery. Multivariate Cox proportional hazards model and Kaplan–Meier curve were used for the prognostic analysis. TT genotype of SNP rs1049434 (MCT1) was significantly associated with better overall survival (OS) (HR = 0.56, P = 0.026) and recurrence-free survival (RFS) (HR = 0.57, P = 0.016) of NSCLC patients. TT genotype of another SNP rs995343 (MCT2) exhibited an association with worse RFS of NSCLC patients (HR = 1.46, P = 0.039). Unfavorable genotypes of SNP rs1049434 and rs995343 showed a significant cumulative effect on OS and RFS of NSCLC patients. Moreover, we found that patients carrying AA+AT genotypes of rs1049434 showed significant OS and RFS benefits from adjuvant chemotherapy, but those with TT genotype did not. Our findings suggest that SNPs in MCT1 and MCT2 genes may affect clinical outcomes and can be used to predict the response to adjuvant chemotherapy in NSCLC patients who received surgical treatment once validated in future study.

Keywords

Non-small cell lung cancer Single nucleotide polymorphisms Monocarboxylate transporters Prognosis 

Notes

Conflicts of interest

None.

Funding

This work was supported by the Program for New Century Excellent Talents in University, National Basic Research Program (2015CB553703).

Supplementary material

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ESM 1 (TIFF 246 kb)
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High resolution image (GIF 20 kb)

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ESM 2 (DOC 105 kb)

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  • Xu Guo
    • 1
    • 2
  • Cheng Chen
    • 1
  • Boya Liu
    • 3
  • Yousheng Wu
    • 1
  • Yibing Chen
    • 1
  • Xingchun Zhou
    • 1
  • Xiaojun Huang
    • 1
  • Xiaofei Li
    • 3
  • Hushan Yang
    • 4
  • Zhinan Chen
    • 2
  • Jinliang Xing
    • 1
  1. 1.State Key Laboratory of Cancer Biology and Experimental Teaching Center of Basic MedicineFourth Military Medical UniversityXi’anChina
  2. 2.State Key Laboratory of Cancer Biology and Cell Engineering Research Center and Department of Cell BiologyFourth Military Medical UniversityXi’anChina
  3. 3.Department of Thoracic Surgery, Tangdu HospitalFourth Military Medical UniversityXi’anChina
  4. 4.Division of Population Science, Department of Medical Oncology, Kimmel Cancer CenterThomas Jefferson UniversityPhiladelphiaUSA

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