Tumor Biology

, Volume 36, Issue 5, pp 3381–3387 | Cite as

MicroRNA-181 functions as a tumor suppressor in non-small cell lung cancer (NSCLC) by targeting Bcl-2

  • Ping Huang
  • Bo Ye
  • Yu Yang
  • Jianxin Shi
  • Heng Zhao
Research Article


MicroRNAs (miRNAs) are small non-coding RNAs frequently dysregulated in human malignancies. In this study, we analyzed the global expression profile of miR-181 in non-small cell lung cancer (NSCLC), as its participation in some other types of cancer has been suggested by previous reports. We found that miR-181 was downregulated both in NSCLC tissues and cell lines. Overexpression of miR-181evidently inhibited A549 cell proliferation, migration, and invasion and promotes cell apoptosis. Moreover, we also found miR-181 reduction was associated with increased Bcl-2 levels and miR-181 was further suggested to exert its pro-apoptotic function mainly through targeting Bcl-2 expression. Taken together, our study implicates important roles of miR-181 in lung cancer pathogenesis and implicates its potential application in cancer therapy.


NSCLC miR-181 Bcl-2 Apoptosis Lung cancer 


Conflicts of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2014

Authors and Affiliations

  • Ping Huang
    • 1
  • Bo Ye
    • 1
  • Yu Yang
    • 1
  • Jianxin Shi
    • 1
  • Heng Zhao
    • 1
  1. 1.Department of Thoracic Surgery, Shanghai Chest HospitalShanghai Jiaotong UniversityShanghaiChina

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