Tumor Biology

, Volume 36, Issue 5, pp 3355–3359 | Cite as

Long noncoding RNA MALAT1 associates with the malignant status and poor prognosis in glioma

  • Kang-xiao Ma
  • Hong-jie Wang
  • Xiao-rong Li
  • Tao Li
  • Gang Su
  • Pan Yang
  • Jian-wen Wu
Research Article


The metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a bona fide long noncoding RNA (lncRNA). LncRNA MALAT1 was discovered as a prognostic factor for lung cancer metastasis but also has been linked to several other human tumor entities. However, little is known about the role of lncRNA MALAT1 in glioma patients. The aim of this study was to identify the role of lncRNA MALAT1 in the pathogenesis of glioma; we analyzed the relationship of lncRNA MALAT1 expression with clinicopathological characteristics in glioma patients. In our results, lncRNA MALAT1 expression was increased in glioma tissues compared with paired adjacent brain normal tissues (P < 0.001). Furthermore, lncRNA MALAT1 was associated significantly with WHO grade (I–II vs. III–IV; P = 0.007) and tumor size (<3 cm vs. T ≥ 3 cm; P = 0.008). However, lncRNA MALAT1 expression was not associated significantly with age (<45 vs. ≥45, P = 0.343), gender (female vs. male, P = 0.196), family history of cancer (yes vs. no, P = 0.665), and tumor location (supratentorial vs. infratentorial, P = 0.170). Moreover, the level of lncRNA MALAT1 expression was markedly correlated with the glioma patients’ overall survival (P < 0.001). Multivariate analysis suggested that increased lncRNA MALAT1 expression was a poor independent prognostic predictor for glioma patients (P = 0.002). In conclusion, lncRNA MALAT1 plays an important role on glioma progression and prognosis and may serve as a convictive prognostic biomarker for glioma patients.


Long noncoding RNA MALAT1 Prognosis Glioma 


Conflicts of interest



  1. 1.
    Siegel R, Ma J, Zou Z, Jemal A. Cancer statistics, 2014. CA Cancer J Clin. 2014;64:9–29.CrossRefPubMedGoogle Scholar
  2. 2.
    Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011;61:69–90.CrossRefPubMedGoogle Scholar
  3. 3.
    Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, et al. The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol. 2007;114:97–109.CrossRefPubMedPubMedCentralGoogle Scholar
  4. 4.
    Dellaretti M, Reyns N, Touzet G, Dubois F, Gusmao S, Pereira JL, et al. Diffuse brainstem glioma: prognostic factors. J Neurosurg. 2012;117:810–4.CrossRefPubMedGoogle Scholar
  5. 5.
    Johnson DR, Galanis E. Incorporation of prognostic and predictive factors into glioma clinical trials. Curr Oncol Rep. 2013;15:56–63.CrossRefPubMedGoogle Scholar
  6. 6.
    Esteller M. Non-coding RNAs in human disease. Nat Rev Genet. 2011;12:861–74.CrossRefPubMedGoogle Scholar
  7. 7.
    Maruyama R, Suzuki H. Long noncoding RNA involvement in cancer. BMB Rep. 2012;45:604–11.CrossRefPubMedPubMedCentralGoogle Scholar
  8. 8.
    Sun Y, Wang Z, Zhou D. Long non-coding RNAs as potential biomarkers and therapeutic targets for gliomas. Med Hypotheses. 2013;81:319–21.CrossRefPubMedGoogle Scholar
  9. 9.
    Qureshi IA, Mehler MF. Emerging roles of non-coding RNAs in brain evolution, development, plasticity and disease. Nat Rev Neurosci. 2012;13:528–41.CrossRefPubMedPubMedCentralGoogle Scholar
  10. 10.
    Han L, Zhang K, Shi Z, Zhang J, Zhu J, Zhu S, et al.: Lncrna pro fi le of glioblastoma reveals the potential role of lncrnas in contributing to glioblastoma pathogenesis. International journal of oncology 2012;40:2004–12Google Scholar
  11. 11.
    Zhang X, Sun S, Pu JK, Tsang AC, Lee D, Man VO, et al. Long non-coding RNA expression profiles predict clinical phenotypes in glioma. Neurobiol Dis. 2012;48:1–8.CrossRefPubMedGoogle Scholar
  12. 12.
    Zhang XQ, Sun S, Lam KF, Kiang KM, Pu JK, Ho AS, et al. A long non-coding RNA signature in glioblastoma multiforme predicts survival. Neurobiol Dis. 2013;58:123–31.CrossRefPubMedGoogle Scholar
  13. 13.
    Zhang JX, Han L, Bao ZS, Wang YY, Chen LY, Yan W, et al. Hotair, a cell cycle-associated long noncoding RNA and a strong predictor of survival, is preferentially expressed in classical and mesenchymal glioma. Neuro-Oncology. 2013;15:1595–603.CrossRefPubMedPubMedCentralGoogle Scholar
  14. 14.
    Zhang X, Zhou Y, Mehta KR, Danila DC, Scolavino S, Johnson SR, et al. A pituitary-derived meg3 isoform functions as a growth suppressor in tumor cells. J Clin Endocrinol Metab. 2003;88:5119–26.CrossRefPubMedGoogle Scholar
  15. 15.
    Tripathi V, Ellis JD, Shen Z, Song DY, Pan Q, Watt AT, et al. The nuclear-retained noncoding RNA malat1 regulates alternative splicing by modulating sr splicing factor phosphorylation. Mol Cell. 2010;39:925–38.CrossRefPubMedPubMedCentralGoogle Scholar
  16. 16.
    Ji P, Diederichs S, Wang W, Boing S, Metzger R, Schneider PM, et al. Malat-1, a novel noncoding RNA, and thymosin beta4 predict metastasis and survival in early-stage non-small cell lung cancer. Oncogene. 2003;22:8031–41.CrossRefPubMedGoogle Scholar
  17. 17.
    Schmidt LH, Spieker T, Koschmieder S, Schaffers S, Humberg J, Jungen D, et al. The long noncoding malat-1 RNA indicates a poor prognosis in non-small cell lung cancer and induces migration and tumor growth. J Thorac Oncol : Off Pub Int Assoc Study Lung Cancer. 2011;6:1984–92.CrossRefGoogle Scholar
  18. 18.
    Luo JH, Ren B, Keryanov S, Tseng GC, Rao UN, Monga SP, et al. Transcriptomic and genomic analysis of human hepatocellular carcinomas and hepatoblastomas. Hepatol (Baltimore). 2006;44:1012–24.CrossRefGoogle Scholar
  19. 19.
    Lin R, Maeda S, Liu C, Karin M, Edgington TS. A large noncoding RNA is a marker for murine hepatocellular carcinomas and a spectrum of human carcinomas. Oncogene. 2007;26:851–8.CrossRefPubMedGoogle Scholar
  20. 20.
    Han Y, Liu Y, Nie L, Gui Y, Cai Z. Inducing cell proliferation inhibition, apoptosis, and motility reduction by silencing long noncoding ribonucleic acid metastasis-associated lung adenocarcinoma transcript 1 in urothelial carcinoma of the bladder. Urology. 2013;81:209 e1–7.CrossRefGoogle Scholar
  21. 21.
    Ying L, Chen Q, Wang Y, Zhou Z, Huang Y, Qiu F. Upregulated malat-1 contributes to bladder cancer cell migration by inducing epithelial-to-mesenchymal transition. Mol BioSyst. 2012;8:2289–94.CrossRefPubMedGoogle Scholar
  22. 22.
    Fellenberg J, Bernd L, Delling G, Witte D, Zahlten-Hinguranage A. Prognostic significance of drug-regulated genes in high-grade osteosarcoma. Mod Pathol : Off J United States Can Acad Pathol. 2007;20:1085–94.CrossRefGoogle Scholar
  23. 23.
    Lai NS, Dong QS, Ding H, Miao ZL, Lin YC. Microrna-210 overexpression predicts poorer prognosis in glioma patients. J Clin Neurosci : Off J Neurosurg Soc Australas. 2014;21:755–60.CrossRefGoogle Scholar
  24. 24.
    Wang P, Ren Z, Sun P. Overexpression of the long non-coding RNA meg3 impairs in vitro glioma cell proliferation. J Cell Biochem. 2012;113:1868–74.CrossRefPubMedGoogle Scholar
  25. 25.
    Guffanti A, Iacono M, Pelucchi P, Kim N, Solda G, Croft LJ, et al. A transcriptional sketch of a primary human breast cancer by 454 deep sequencing. BMC Genomics. 2009;10:163.CrossRefPubMedPubMedCentralGoogle Scholar
  26. 26.
    Praz V, Jagannathan V, Bucher P. Cleanex: a database of heterogeneous gene expression data based on a consistent gene nomenclature. Nucleic Acids Res. 2004;32:D542–7.CrossRefPubMedPubMedCentralGoogle Scholar
  27. 27.
    Yamada K, Kano J, Tsunoda H, Yoshikawa H, Okubo C, Ishiyama T, et al. Phenotypic characterization of endometrial stromal sarcoma of the uterus. Cancer Sci. 2006;97:106–12.CrossRefPubMedGoogle Scholar
  28. 28.
    Tripathi V, Shen Z, Chakraborty A, Giri S, Freier SM, Wu X, et al. Long noncoding RNA MALAT1 controls cell cycle progression by regulating the expression of oncogenic transcription factor B-MYB. PLoS Genet. 2013;9:e1003368.CrossRefPubMedPubMedCentralGoogle Scholar
  29. 29.
    Guo F, Li Y, Liu Y, Wang J, Li Y, Li G. Inhibition of metastasis-associated lung adenocarcinoma transcript 1 in CaSki human cervical cancer cells suppresses cell proliferation and invasion. Acta Biochim Biophys Sin. 2010;42:224–9.CrossRefPubMedGoogle Scholar
  30. 30.
    Lai MC, Yang Z, Zhou L, Zhu QQ, Xie HY, Zhang F, et al. Long non-coding RNA MALAT-1 overexpression predicts tumor recurrence of hepatocellular carcinoma after liver transplantation. Med Oncol (London, England). 2012;29:1810–6.Google Scholar

Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  • Kang-xiao Ma
    • 2
  • Hong-jie Wang
    • 1
  • Xiao-rong Li
    • 1
  • Tao Li
    • 1
  • Gang Su
    • 1
  • Pan Yang
    • 1
  • Jian-wen Wu
    • 1
  1. 1.Department of NeurosurgeryThe Fourth People’s Hospital of JinanJinanChina
  2. 2.Department of NeurosurgeryThe Ninth People’s Hospital of Xi’anXi’anChina

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