Tumor Biology

, Volume 36, Issue 5, pp 3319–3324 | Cite as

The tumor suppressor role of PAQR3 in osteosarcoma

  • Zhiqiang Ma
  • Yanlong Wang
  • Taikui Piao
  • Zhaopeng Li
  • Hongyu Zhang
  • Zhixin Liu
  • Jianyu Liu
Research Article


Osteosarcoma is the most common primary bone malignancy; however, the molecular mechanisms of development are not well understood. Progestin and AdipoQ receptors (PAQR3), a protein specifically localized in the Golgi apparatus, was recently characterized as a new tumor suppressor. Little is known about the expression and function of PAQR3 in osteosarcoma. Here, we showed that PAQR3 was downregulated in osteosarcoma tissues compared with the adjacent normal regions in 80 paired samples. Moreover, lower levels of PAQR3 were associated with metastasis in clinical osteosarcoma patients. In addition, overexpression of PAQR3 in the osteosarcoma cell line MG-63 inhibited cell proliferation, migration, and invasion by promoting ERK phosphorylation. Taken together, our results indicated that PAQR3 might act as a tumor suppressor in osteosarcoma, providing a novel diagnostic and therapeutic option for human osteosarcoma in the future.


Osteosarcoma Tumor suppressor PAQR3 ERK1/2 



This research project was supported by the National Natural Science Foundation of China grant No. 81272015 and Heilongjiang Postdoctoral Fund No. LBH-Z12189.

Conflicts of interest


Supplementary material

13277_2014_2964_MOESM1_ESM.doc (43 kb)
ESM 1 (DOC 43 kb)


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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2014

Authors and Affiliations

  • Zhiqiang Ma
    • 1
  • Yanlong Wang
    • 1
  • Taikui Piao
    • 2
  • Zhaopeng Li
    • 1
  • Hongyu Zhang
    • 1
  • Zhixin Liu
    • 1
  • Jianyu Liu
    • 1
  1. 1.Department of Orthopedic SurgeryThe Second Hospital of Harbin Medical UniversityHarbinPeople’s Republic of China
  2. 2.Children’s Hospital of HarbinHarbinPeople’s Republic of China

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