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Tumor Biology

, Volume 36, Issue 3, pp 1323–1327 | Cite as

Bevacizumab in combination with anticancer drugs for previously treated advanced non-small cell lung cancer

  • Ke-jun Liu
  • Ling-yu Ding
  • Hai-ying Wu
Review

Abstract

Non-small cell lung cancer (NSCLC) accounts for about 85 % of all lung cancer cases. Patients with NSCLC often have an advanced disease at the time of diagnosis, with a 1-year survival rate about 10–15 % under the best support treatment. As therapeutic methods for lung cancer developed rapidly in recent years, the prognosis of stage IIIB or IV NSCLC also improve to a large extend. Bevacizumab is a monoclonal antibody against VEGFR which inhibits abnormal vascular growth in malignant tumors. In October 2006, bevacizumab was approved by the U.S. Food and Drug Administration (FDA) for first-line use in advanced NSCLC. For patients with advanced NSCLC who failed in previously platinum-based chemotherapy, bevacizumab also showed enhancing efficacy to antitumor drugs recommended by the latest NCCN guideline. This review intends to present the recent progress and prospects of bevacizumab in second- or third-line treatment for patients with refractory NSCLC.

Keywords

Non-small cell lung cancer (NSCLC) Bevacizumab Platinum-based chemotherapy 

Abbreviation

NSCLC

Non-small cell lung cancer

SCLC

Small cell lung cancer

FDA

The U.S. Food and Drug Administration

ECOG

Eastern Cooperative Oncology Group

SD

Stable disease

PR

Partial remission

CNS

Central nervous system

RECIST

Response Evaluation Criteria in Solid Tumors

PFS

Progression-free survival

OS

Overall survival

EGFR

Epidermal growth factor receptor

VEGFR

Vascular epidermal growth factor receptor

Notes

Conflicts of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  1. 1.Department of Medical OncologySun Yat-Sen University Cancer CenterGuangzhouChina
  2. 2.State Key Laboratory of Oncology in South ChinaGuangzhouChina
  3. 3.Collaborative Innovation Center of Cancer MedicineGuangzhouChina
  4. 4.Department of Medical OncologyDongguan People’s HospitalDongguanChina

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