Tumor Biology

, Volume 36, Issue 4, pp 2965–2971 | Cite as

Tumor-infiltrating neutrophils predict poor outcome in adenocarcinoma of the esophagogastric junction

  • Pingping Hu
  • Zhaofei Pang
  • Hongchang Shen
  • Guanghui Wang
  • Haifeng Sun
  • Jiajun Du
Research Article


Tumor-infiltrating neutrophil (TIN) has been reported to be an independent predictor in multiple tumors, but its role in the development of adenocarcinoma of the esophagogastric junction (AEG) remains unclear. We conducted immunohistochemistry (IHC) to detect the expression of TIN in 113 consecutive patients with primary AEG. The prognostic value and its relationship with clinicopathological characteristics and Ki-67 (a proliferation-associated antigen) expression were analyzed. High level of TIN was related to poor outcome in AEG patients with a hazard ratio (HR) of 3.93 (95 % confidence interval (CI) = 2.14–7.19, p < 0.001) in univariate analysis and a HR of 3.44 (95 % CI = 1.85–6.37, p < 0.001) in multivariate analysis. In addition, TIN was positively correlated with Ki-67 expression (p = 0.008). Our study found that TIN expression was an independent unfavorable predictor in AEG. Furthermore, the relationship between TIN and Ki-67 indicated that TIN was associated with tumor proliferation, which might provide a potential mechanism for why TIN was related to poor outcome in AEG.


Tumor-infiltrating neutrophils Adenocarcinoma of esophagogastric junction Ki-67 Tumor proliferation Prognosis 



The work was supported by the National Natural Science Foundation of China (81301728) and the Provincial Natural Science Foundation of Shandong (ZR2013HZ001).

Conflicts of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2014

Authors and Affiliations

  • Pingping Hu
    • 1
  • Zhaofei Pang
    • 2
  • Hongchang Shen
    • 3
  • Guanghui Wang
    • 2
  • Haifeng Sun
    • 2
  • Jiajun Du
    • 1
    • 2
  1. 1.Institute of Oncology, Shandong Provincial Hospital Affiliated to Shandong UniversityShandong UniversityJinanChina
  2. 2.Department of Thoracic Surgery, Shandong Provincial Hospital Affiliated to Shandong UniversityShandong UniversityJinanChina
  3. 3.Department of Oncology, Shandong Provincial Hospital Affiliated to Shandong UniversityShandong UniversityJinanChina

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