Tumor Biology

, Volume 36, Issue 4, pp 2863–2868 | Cite as

Different frequencies and effects of ABCB1 T3435C polymorphism on clinical and laboratory features of B cell chronic lymphocytic leukemia in Kurdish patients

Research Article

Abstract

Finding the effects of gene polymorphism on cancer pathogenesis is very desirable. The ATP-binding cassette is involved in drug metabolism, and the polymorphism of this gene may be an important risk factor in B cell chronic lymphocytic leukemia (B-CLL) or progression and/or response to chemotherapy agents. For the first time, the present study was aimed to evaluate the probable effects of ABCB1 T3435C polymorphism on clinical and laboratory features of Kurdish patients with B-CLL. This descriptive analytical case-control study was performed on 50 B-CLL patients and 100 healthy subjects. Serum levels of beta-2-microglobulin (B2M) and lactate dehydrogenase (LDH) and blood WBC, RBC, Plt and ESR were measured. The T3435C polymorphism of the ABCB1 gene was determined by PCR-RFLP. Concentration of serum and blood markers was significantly higher in the malignant group than in the benign subjects. The CC genotype had the highest frequency (66 %) in the patient groups. There are no significant differences between the genotypes and type of treatment. Our results demonstrate the high frequency of C allele of ABCB1 T3435C in B-CLL patients with Kurdish ethnicity. We also show that this polymorphism has a significant risk factor in B-CLL. However, the effect of this polymorphism on clinical and laboratory characteristics of B-CLL patients was not significant.

Keywords

B-CLL ABCB1 T3435C polymorphism Chemotherapy agents B2M 

Notes

Acknowledgments

The authors wish to thank all patients and health staff who participated in this study. This work has no financially support.

Conflicts of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  1. 1.Department of Biochemistry, College of Science, Kurdistan Science and Research BranchIslamic Azad UniversitySanandajIran
  2. 2.Department of Biology, College of ScienceIslamic Azad UniversitySanandajIran
  3. 3.Department of Epidemiology and Biostatistics, Faculty of MedicineKurdistan University of Medical SciencesSanandajIran
  4. 4.Department of Internal Medicine, Faculty of MedicineKurdistan University of Medical SciencesSanandajIran
  5. 5.Cellular and Molecular Research Center, Faculty of MedicineKurdistan University of Medical SciencesSanandajIran
  6. 6.Department of Clinical Biochemistry, Faculty of MedicineKurdistan University of Medical SciencesSanandajIran
  7. 7.Division of Hematology-OncologyTohid HospitalSanandajIran

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