Advertisement

Tumor Biology

, Volume 36, Issue 4, pp 2815–2819 | Cite as

RETRACTED ARTICLE: Augmented TGFβ receptor signaling induces apoptosis of pancreatic carcinoma cells

  • Chenggang Li
  • Zhiming Zhao
  • Zhipeng Zhou
  • Rong Liu
Research Article

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is an extremely malignant tumor in humans. Thus, understanding the tumorigenesis of PDAC appears to help develop efficient therapy. Here, we show that activated TGFβ receptor signaling induces apoptosis of pancreatic carcinoma cells in vitro and in vivo, suggesting that activation of TGFβ receptor signaling may prevent development of PDAC.

Keywords

Pancreatic ductal adenocarcinoma TGFβ Apoptosis 

Notes

Conflicts of interest

None.

References

  1. 1.
    Han H, Von Hoff DD: Snapshot: pancreatic cancer. Cancer Cell 2013;23:424-424 e421Google Scholar
  2. 2.
    Shi W, Yin J, Chen Z, Chen H, Liu L, Meng Z: Cyr61 promotes growth of pancreatic carcinoma via nuclear exclusion of p27. Tumour Biol 2014Google Scholar
  3. 3.
    Massague J. TGFbeta in cancer. Cell. 2008;134:215–30.CrossRefPubMedPubMedCentralGoogle Scholar
  4. 4.
    Yi JJ, Barnes AP, Hand R, Polleux F, Ehlers MD. TGF-beta signaling specifies axons during brain development. Cell. 2010;142:144–57.CrossRefPubMedPubMedCentralGoogle Scholar
  5. 5.
    Naka K, Hoshii T, Muraguchi T, Tadokoro Y, Ooshio T, Kondo Y, et al. TGF-beta-foxo signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia. Nature. 2010;463:676–80.CrossRefPubMedGoogle Scholar
  6. 6.
    Xiao X, Wiersch J, El-Gohary Y, Guo P, Prasadan K, Paredes J, et al. TGFbeta receptor signaling is essential for inflammation-induced but not beta-cell workload-induced beta-cell proliferation. Diabetes. 2013;62:1217–26.CrossRefPubMedPubMedCentralGoogle Scholar
  7. 7.
    Xiao X, Gaffar I, Guo P, Wiersch J, Fischbach S, Peirish L, et al. M2 macrophages promote beta-cell proliferation by up-regulation of smad7. Proc Natl Acad Sci U S A. 2014;111:E1211–20.CrossRefPubMedPubMedCentralGoogle Scholar
  8. 8.
    El-Gohary Y, Tulachan S, Guo P, Welsh C, Wiersch J, Prasadan K, et al. Smad signaling pathways regulate pancreatic endocrine development. Dev Biol. 2013;378:83–93.CrossRefPubMedPubMedCentralGoogle Scholar
  9. 9.
    Truty MJ, Urrutia R. Basics of TGF-beta and pancreatic cancer. Pancreatology. 2007;7:423–35.CrossRefPubMedGoogle Scholar
  10. 10.
    Muller-Pillasch F, Menke A, Yamaguchi H, Elsasser HP, Bachem M, Adler G, et al. TGFbeta and the extracellular matrix in pancreatitis. Hepatogastroenterology. 1999;46:2751–6.PubMedGoogle Scholar
  11. 11.
    Jackson EL, Willis N, Mercer K, Bronson RT, Crowley D, Montoya R, et al. Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-RAS. Genes Dev. 2001;15:3243–8.CrossRefPubMedPubMedCentralGoogle Scholar
  12. 12.
    Gidekel Friedlander SY, Chu GC, Snyder EL, Girnius N, Dibelius G, Crowley D, et al. Context-dependent transformation of adult pancreatic cells by oncogenic K-RAS. Cancer Cell. 2009;16:379–89.CrossRefPubMedPubMedCentralGoogle Scholar
  13. 13.
    Kawaguchi Y, Cooper B, Gannon M, Ray M, MacDonald RJ, Wright CV. The role of the transcriptional regulator PTF1A in converting intestinal to pancreatic progenitors. Nat Genet. 2002;32:128–34.CrossRefPubMedGoogle Scholar
  14. 14.
    Jimenez V, Ayuso E, Mallol C, Agudo J, Casellas A, Obach M, et al. In vivo genetic engineering of murine pancreatic beta cells mediated by single-stranded adeno-associated viral vectors of serotypes 6, 8 and 9. Diabetologia. 2011;54:1075–86.CrossRefPubMedGoogle Scholar
  15. 15.
    Xiao X, Guo P, Prasadan K, Shiota C, Peirish L, Fischbach S, et al. Pancreatic cell tracing, lineage tagging and targeted genetic manipulations in multiple cell types using pancreatic ductal infusion of adeno-associated viral vectors and/or cell-tagging dyes. Nat Protoc. 2014;9:2719–24.CrossRefPubMedPubMedCentralGoogle Scholar
  16. 16.
    Lieber M, Mazzetta J, Nelson-Rees W, Kaplan M, Todaro G. Establishment of a continuous tumor-cell line (panc-1) from a human carcinoma of the exocrine pancreas. Int J Cancer. 1975;15:741–7.CrossRefPubMedGoogle Scholar
  17. 17.
    Mei Q, Li F, Quan H, Liu Y, Xu H. Busulfan inhibits growth of human osteosarcoma through mir-200 family microRNAs in vitro and in vivo. Cancer Sci. 2014;105:755–62.CrossRefPubMedPubMedCentralGoogle Scholar
  18. 18.
    di Magliano MP, Logsdon CD. Roles for KRAS in pancreatic tumor development and progression. Gastroenterology. 2013;144:1220–9.CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2014

Authors and Affiliations

  • Chenggang Li
    • 1
  • Zhiming Zhao
    • 1
  • Zhipeng Zhou
    • 1
  • Rong Liu
    • 1
  1. 1.Department of Surgical OncologyChinese PLA General HospitalBeijingChina

Personalised recommendations