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Tumor Biology

, Volume 36, Issue 4, pp 2709–2724 | Cite as

Promoter polymorphism of FASL confers protection against female-specific cancers and those of FAS impact the cancers divergently

  • Sateesh Reddy Nallapalle
  • Sarika Daripally
  • V. T. S Vidudala Prasad
Research Article

Abstract

We investigated risk association of FAS (−1377 G>A and −670 A>G) and FASL (−844 T>C) promoter polymorphisms with breast, ovarian, cervical, and endometrial cancers and report that the FASL −844 CC genotype was protective against breast, ovarian, cervical, and endometrial cancers (P ≤ 0.01). On the other hand, FAS −1377 GA and AA variants increased risk of breast cancer. However, the GA variant of FAS −1377 was also found to be a risk factor for cervical cancer. In contrast, FAS −670 AG variant significantly lowered risk of breast cancer. Further, we also observed that risk association of co-occurrence of FAS and/or FASL variants with the cancers varied as compared to the presence of individual polymorphisms. Although risk and protective haplotypes of FAS SNPs were observed across the cancer phenotypes, the association of the haplotypes was significant for breast cancer alone with a 3-fold enhanced risk. The protective effect of the FASL CC genotype seen in this study suggests that similar biomolecular mechanisms involving FASL might play a role in female-specific cancers.

Keywords

FAS FASL Breast cancer Ovarian cancer Cervical cancer Endometrial cancer Gynecological cancers 

Notes

Acknowledgments

The research was partly funded by a grant from Indian Council of Medical Research (ICMR), New Delhi (to VVTSP; grant no. 5/8/10-3(Oto)/CFP/11-NCD-1), and by Basavatarakam Indo-American Cancer Hospital and Research Institute (BIACH&RI), Hyderabad, India. Mr. Sateesh works for the ICMR grant. Mrs. Sarika is thankful to Council for Scientific and Industrial Research, Government of India, for the award of Junior Research Fellow. We also like to thank Acharya Nagarjuna University, Nagarjuna Nagar, AP, India, for registering Mrs. Sarika for her doctoral degree. We would like to thank Dr. SarithaKatta,volunteer researcher at the R&D, BIACH&RI, for her help in preparing the manuscript. We also acknowledge the technical help provided by the research assistants of the R&D.

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2014

Authors and Affiliations

  • Sateesh Reddy Nallapalle
    • 1
  • Sarika Daripally
    • 1
    • 2
  • V. T. S Vidudala Prasad
    • 1
  1. 1.Research and DevelopmentBasavatarakam Indo-American Cancer Hospital and Research Institute (BIACH&RI)HyderabadIndia
  2. 2.Acharya Nagarjuna UniversityAndhra PradeshIndia

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