Tumor Biology

, Volume 36, Issue 1, pp 121–127 | Cite as

Polymorphisms in IL-4/IL-13 pathway genes and glioma risk: an updated meta-analysis

  • Peiqin Chen
  • Chao Chen
  • Kun Chen
  • Tao Xu
  • Chun Luo


Polymorphisms in interleukin (IL)-4/IL-13 pathway genes have previously been reported to be associated with glioma susceptibility, although results are inconsistent. We therefore performed an updated meta-analysis to determine a more precise estimation of this relationship. Twelve eligible studies were identified by searching PubMed, EMBASE, Web of Science, and the Cochrane Library electronic databases. Nine polymorphisms in genes within the IL-4/IL-13 pathway (IL-4 rs2243250, rs2070874, rs2243248, IL-4R rs1805011, rs1805012, rs1805015, rs1801275, and IL-13 rs20541 and rs1800925) were assessed for their relationship with glioma risk by computing odds ratios (ORs) and corresponding 95 % confidence intervals (CIs). Akaike’s information criterion (AIC) was used to identify the best genetic model for each polymorphism. No association between IL-4/IL-13 pathway genetic polymorphisms and glioma risk was observed in the overall population, although a significant association was found between rs2234248 and glioblastoma when stratified by histological subtype (log-additive model, OR 1.57, 95 % CI 1.11–2.24). This meta-analysis therefore suggested that IL-4/IL-13 pathway genetic polymorphisms are not associated with glioma risk.


Glioma Meta-analysis Interleukin-4 Interleukin-4R Interleukin-13 Single nucleotide polymorphism 



We thank Dr. Melissa L. Bondy from the Texas MD Anderson Cancer Center and Dr. Kyle M. Walsh from the Helen Diller Family Comprehensive Cancer Center for generously providing their data.

Conflicts of interest


Supplementary material

13277_2014_2895_MOESM1_ESM.doc (39 kb)
Online Resource 1 Scale for methodological quality assessment (DOC 39 kb)
13277_2014_2895_Fig4_ESM.gif (123 kb)
Online Resource 2

Meta-analysis for the association between IL-4/IL-13 pathway genetic polymorphisms and glioblastoma risk (GIF 122 kb)

13277_2014_2895_MOESM2_ESM.eps (1.5 mb)
High resolution image (EPS 1527 kb)


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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2014

Authors and Affiliations

  • Peiqin Chen
    • 1
  • Chao Chen
    • 2
  • Kun Chen
    • 1
  • Tao Xu
    • 1
  • Chun Luo
    • 1
  1. 1.Department of Neurosurgery, Changzheng HospitalSecond Military Medical UniversityShanghaiChina
  2. 2.Department of Neurosurgery, Changhai HospitalSecond Military Medical UniversityShanghaiChina

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