Tumor Biology

, Volume 36, Issue 4, pp 2607–2612 | Cite as

Ginsenoside Rh2 inhibits growth of glioblastoma multiforme through mTor

Research Article

Abstract

Being the most malignant primary brain tumor in humans, glioblastoma multiforme (GBM) has a fairly poor patient survival after current combined treatment with chemotherapy, radiation, and surgery. Ginsenoside Rh2 (GRh2) has been reported to have a therapeutic effect on some tumors, and we recently reported its inhibitory effect on GBM growth in vitro and in vivo, possibly through an epidermal growth factor receptor (EGFR) signaling pathway. Here, using specific inhibitors, we found that the activation of EGFR signaling promoted GBM growth through PI3k/Akt/mTor signaling pathways. Moreover, GRh2 efficiently inhibited activation of this pathway at the receptor level. Together with our previous findings, these data suggest that GRh2 may suppress GBM growth through its competition with EGFR ligands for binding to the EGFR, and binding to EGFR by GRh2 does not lead to receptor phosphorylation. Thus, our data highlight a previous unappreciated role for GRh2 to inhibit EGFR signaling. GRh2 thus appears to be a promising therapy for cancers that require EGFR signaling to growth.

Keywords

Glioblastoma multiforme (GBM) Ginsenoside Rh2 (GRh2) Epidermal growth factor receptor (EGFR) PI3k mTor 

Notes

Acknowledgments

This work was supported by the Natural Science Foundation of China (No. 30772246, No. 81072655), Liaoning Provincial Department of Education Science Research Foundation (L2010586), Liaoning Provincial Natural Science Foundation (201202286), and Shengjing Free Researcher Project (2011).

Conflicts of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2014

Authors and Affiliations

  1. 1.Department of NeurosurgeryShengjing Hospital of China Medical UniversityShenyangChina
  2. 2.He UniversityShenyangChina

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