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Tumor Biology

, Volume 36, Issue 4, pp 2583–2591 | Cite as

CIZ1 promoted the growth and migration of gallbladder cancer cells

  • Dexiang Zhang
  • Yueqi Wang
  • Yuedi Dai
  • Jiwen Wang
  • Tao Suo
  • Hongtao Pan
  • Han Liu
  • Sheng Shen
  • Houbao Liu
Research Article

Abstract

Gallbladder cancer (GBC) is one of the most common and aggressive diseases among the gastrointestinal tract malignancies, and the molecular mechanism underlying this disease remains largely unknown. CIZ1 (Cip1 interacting zinc finger protein 1), a binding partner of p21Cip1/Waf1, has been found to be involved in the tumorigenesis recently. However, the expression pattern and biological functions of CIZ1 in the progression of GBC are not fully understood. In this study, it was found that the expression of CIZ1 was significantly elevated in GBC samples compared to their adjacent normal tissues. Moreover, overexpression of CIZ1 promoted the growth and migration of GBC cells, while knocking down the expression of CIZ1 inhibited the growth, migration, and tumorigenesis of GBC cells in vitro and in vivo. Mechanistically, CIZ1 was found to interact with TCF4 (T-cell factor) and activate beta-catenin/TCF signaling. Our study demonstrated that CIZ1 played an oncogenic role in the progression of GBC and CIZ1 might be a promising target for the treatment of GBC.

Keywords

CIZ1 Gallbladder cancer Cell growth and migration Beta-catenin/TCF 

Notes

Acknowledgment

This work was supported by the National Natural Science Foundation of China (81272728), the Foundation of Shanghai Science and Technology IIJC1416202, and the Foundation 201440338 from Shanghai.

Conflicts of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2014

Authors and Affiliations

  • Dexiang Zhang
    • 1
  • Yueqi Wang
    • 1
  • Yuedi Dai
    • 2
  • Jiwen Wang
    • 1
  • Tao Suo
    • 1
  • Hongtao Pan
    • 1
  • Han Liu
    • 1
  • Sheng Shen
    • 1
  • Houbao Liu
    • 1
  1. 1.General Surgery Department, Zhongshan Hospital, General Surgery InstituteFudan UniversityShanghaiChina
  2. 2.Department of Medical OncologyCancer Hospital of Fudan University, Minhang BranchShanghaiChina

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