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Tumor Biology

, Volume 36, Issue 1, pp 81–94 | Cite as

Warburg meets non-coding RNAs: the emerging role of ncRNA in regulating the glucose metabolism of cancer cells

Review

Abstract

Unlike normal differentiated cells, cancer cells primarily rely on glycolysis to generate energy needed for cellular processes even in normoxia conditions. This phenomenon is called aerobic glycolysis or “the Warburg effect.” Aerobic glycolysis is inefficient to generate ATP, but the advantages it confers to cancer cells remain to be fully explained. Several oncogenic signaling pathways, interplaying with enzymes and kinases involved in glucose metabolism, participate in the switch from oxidative phosphorylation (OXPHOS) to aerobic glycolysis. Non-coding RNAs (ncRNAs) are a family of functional RNA molecules that are not further translated into proteins, which exert regulatatory roles in gene transcription and translation. ncRNAs, especially miRNAs and long non-coding RNAs (lncRNAs), may also have great effect on glucose metabolism by targeting not only glycolysis enzymes directly but also oncogenic signaling pathways indirectly. A better understanding of the Warburg effect and the regulatory role of ncRNAs in cancer glucose metabolism may contribute to the treatment of cancers.

Keywords

Warburg effect Aerobic glycolysis Glucose metabolism Non-coding RNA (ncRNA) MicroRNA (miRNA) Long non-coding RNA (lncRNA) 

Notes

Acknowledgments

This work is supported by the National Natural Science Foundation of China (81472917, 81302382, and 81472920), the Key Programs of Natural Science Foundation of Jiangsu Educational Committee (11KJA310001), and the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD).

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2014

Authors and Affiliations

  1. 1.School of Radiation Medicine and Protection and Jiangsu Provincial Key Laboratory of Radiation Medicine and ProtectionMedical College of Soochow UniversitySuzhouChina
  2. 2.Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions and School for Radiological and Interdisciplinary Sciences (RAD-X)Soochow UniversitySuzhouChina

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