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Tumor Biology

, Volume 36, Issue 1, pp 55–67 | Cite as

Active radar guides missile to its target: receptor-based targeted treatment of hepatocellular carcinoma by nanoparticulate systems

  • Jing-Jun Yan
  • Jia-Zhi Liao
  • Ju-Sheng Lin
  • Xing-Xing He
Review

Abstract

Patients with hepatocellular carcinoma (HCC) usually present at advanced stages and do not benefit from surgical resection, so drug therapy should deserve a prominent place in unresectable HCC treatment. But chemotherapy agents, such as doxorubicin, cisplatin, and paclitaxel, frequently encounter important problems such as low specificity and non-selective biodistribution. Recently, the development of nanotechnology led to significant breakthroughs to overcome these problems. Decorating the surfaces of nanoparticulate-based drug carriers with homing devices has demonstrated its potential in concentrating chemotherapy agents specifically to HCC cells. In this paper, we reviewed the current status of active targeting strategies for nanoparticulate systems based on various receptors such as asialoglycoprotein receptor, transferrin receptor, epidermal growth factor receptor, folate receptor, integrin, and CD44, which are abundantly expressed on the surfaces of hepatocytes or liver cancer cells. Furthermore, we pointed out their merits and defects and provided theoretical references for further research.

Keywords

Active drug delivery Nanotechnology Asialoglycoprotein receptor EGFR Transferrin receptor Folate receptor 

Abbreviations

HCC

Hepatocellular carcinoma

ASGPR

Asialoglycoprotein receptor

EGFR

Epidermal growth factor receptor

TfR

Transferrin receptor

FR

Folate receptor

PTX

Paclitaxel

DOX

Doxorubicin

LA

Lactobionic acid

HCPT

10-Hydroxycamptothecin

5-FU

5-Fluorouracil

RBV

Ribavirin

siRNA

Small interfering RNA

shRNA

Short hairpin RNA

miRNA

microRNA

RBITC

Rhodamine B isothiocyanate

PHA

Polyhydroxyalkanoates

PhaP

PHA granule-binding protein

LPEI

Linear polyethylenimine

PEG

Polyethylene glycol

NIS

Sodium iodide symporter

QD

Quantum dot

DENA

Diethylnitrosamine

ECM

Extracellular matrix

CSCs

Cancer stem cells

HA

Hyaluronan

GA

Glycyrrhetinic acid

GPC3

Glypican-3

SSTRs

Somatostatin receptors

VEGFR

Vascular endothelial growth factor

Notes

Acknowledgments

This work was supported by grants from the National Natural Science Foundation of China (Nos. 81472832, 81302112, and 81372663), the Outstanding Youth Science Foundation of Tongji Hospital (No. YXQN005), the Youth Sciences and Technology Chenguang Planning of Wuhan (No. 2014070404010219), and the Fundamental Research Funds for the Central Universities (No. 2014QN084).

Conflicts of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2014

Authors and Affiliations

  • Jing-Jun Yan
    • 1
  • Jia-Zhi Liao
    • 1
  • Ju-Sheng Lin
    • 1
  • Xing-Xing He
    • 1
  1. 1.Institute of Liver Diseases, Tongji Hospital, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina

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