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Tumor Biology

, Volume 36, Issue 4, pp 2377–2381 | Cite as

Inhibition of prostatic cancer growth by ginsenoside Rh2

Research Article

Abstract

Ginsenoside Rh2 (GRh2) has been reported to have therapeutic effects on some types of cancer, but its effect on prostatic cancer has not been extensively evaluated. Here, we show that GRh2 can substantially inhibit the growth of prostatic cancer in vivo and in vitro. Moreover, the inhibition of the tumor growth appeared to result from a combined inhibitory effect on tumor cell proliferation and tumor cell invasiveness. Further analyses suggest that GRh2 seemed to activate transforming growth factor β (TGFβ) receptor signaling in prostatic cancer cells, which subsequently inhibits cell proliferation and invasion through regulating cell-cycle controllers and (MMPs), respectively. Taken together, our data reveal an essential anti-prostatic cancer effect of GRh2 and demonstrate that this effect is through augment of TGFβ receptor signaling in the prostatic cancer cells. GRh2 thus appears to be a promising therapy for prostatic cancer.

Keywords

Prostatic cancer Ginsenoside Rh2 Transforming growth factor β receptor signaling SMAD2 

Notes

Conflicts of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2014

Authors and Affiliations

  • Qingchuan Zhang
    • 1
  • Bin Hong
    • 1
  • Songhua Wu
    • 1
  • Tianli Niu
    • 1
  1. 1.Department of Urology, Putuo Hospital,Shanghai University of Traditional Chinese MedicineShanghaiChina

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