Tumor Biology

, Volume 36, Issue 4, pp 2351–2357 | Cite as

Stoichiometric expression of MMP-2/TIMP-2 in benign and malignant tumours of the salivary gland

  • Bamidele Kolude
  • Akinyele Olumuyiwa Adisa
  • Ahmed Oluwatoyin Lawal
  • Bukola Folasade Adeyemi
  • Akindayo Olufunto Akinyamoju
Research Article
  • 95 Downloads

Abstract

The aim of this study was to determine the expression of matrix metalloproteinase 2 (MMP-2) and tissue inhibitors of matrix metalloproteinase 2 (TIMP-2) and the MMP-2/TIMP-2 expression ratio in salivary gland tumours (SGTs). Forty-three FFPE SGTs were prepared for antibody processing to MMP-2 and TIMP-2. Two investigators utilizing Sinicrope’s method scored the uptake of immuno-stains. Cytoplasmic staining was considered as positive. Data was analysed using SPSS version 20. The significance level was set at p < 0.05. In benign SGTs, the mean score for MMP-2 was not significantly lower than that of TIMP-2 (p = 0.37). However, the mean scores for MMP-2 stain intensity and proportion were significantly higher in malignant than benign SGTs (p = 0.01 and p = 0.02 respectively). There was no significant difference in the mean MMP-2/TIMP-2 expression ratio of the malignant SGTs according to histological grade and histogenesis (p = 0.4 and p = 0.19 respectively). The MMP-2/TIMP-2 expression ratio has a higher prognostic value than the separate expressions of MMP-2 and TIMP-2.

Keywords

Matrix metalloproteinase-2 Tissue inhibitor of matrix metalloproteinase-2 Salivary gland tumours 

Notes

Financial support

All the authors declare that there are no disclosures to make and that this was a self-funded study.

Conflicts of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2014

Authors and Affiliations

  • Bamidele Kolude
    • 1
  • Akinyele Olumuyiwa Adisa
    • 1
  • Ahmed Oluwatoyin Lawal
    • 1
  • Bukola Folasade Adeyemi
    • 1
  • Akindayo Olufunto Akinyamoju
    • 1
  1. 1.Department of Oral Pathology, Faculty of Dentistry, College of MedicineUniversity of IbadanIbadanNigeria

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