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Tumor Biology

, Volume 36, Issue 4, pp 2271–2276 | Cite as

Lung metastasis of pancreatic carcinoma is regulated by TGFβ signaling

  • Liqiang Song
  • Ping Wang
  • Yu Tian
  • De Chang
  • Kailong Li
  • Yongna Fan
  • Jing Shen
  • Hongzhen Du
  • Ruifang Mi
  • Xiaoxia Bian
  • Xianchao Tang
Research Article

Abstract

The molecular regulation of the lung metastasis of pancreatic carcinoma (PCC) is not completely understood. Here, we show that the levels of phosphorylated SMAD3, ZEB1, ZEB2, Snail1, and Snail2 were significantly higher in PCC with lung metastasis than in PCC without lung metastasis. Overexpression of TGFβ1 enhanced the invasiveness of PCC cells, while inhibition of TGFβ1 decreased the invasiveness of PCC cells, which appeared to be conducted by activated TGFβ receptor signaling-induced upregulation of ZEB1, ZEB2, Snail1, and Snail2, suggesting a process of epithelial-mesenchymal transition (EMT). Taken together, our study provides evidence that TGFβ receptor signaling-induced EMT may be responsible for the increased PCC invasiveness to enhance its lung metastasis.

Keywords

Lung metastasis Pancreatic carcinoma Transforming growth factor β Epithelial-mesenchymal transition 

Notes

Conflicts of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2014

Authors and Affiliations

  • Liqiang Song
    • 1
  • Ping Wang
    • 2
  • Yu Tian
    • 3
  • De Chang
    • 1
    • 5
  • Kailong Li
    • 1
  • Yongna Fan
    • 1
  • Jing Shen
    • 1
  • Hongzhen Du
    • 1
  • Ruifang Mi
    • 1
    • 4
  • Xiaoxia Bian
    • 1
  • Xianchao Tang
    • 1
  1. 1.Department of Pathology, Institute of Basic Medical Sciences and School of Basic MedicineChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina
  2. 2.Department of RespiratoryThe Forth Hospital Affiliated to Heibei Medical UniversityShijiazhuangChina
  3. 3.Department of OncologyMilitary Subarea Hospital of Alxa LeagueNeimengguChina
  4. 4.Brain Tumor Research Center, Beijing Neurosurgical InstituteBeijing Tiantan Hospital Affiliated to Capital Medical UniversityBeijingChina
  5. 5.Department of Respiratory MedicineGeneral Hospital of Chinese People’s Armed Police ForcesBeijingChina

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