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Tumor Biology

, Volume 36, Issue 3, pp 2169–2178 | Cite as

High expression of astrocyte elevated gene-1 is associated with clinical staging, metastasis, and unfavorable prognosis in gastric carcinoma

  • Liangpeng Dong
  • Shuang Qin
  • Yan Li
  • Lunde Zhao
  • Shuping Dong
  • Ying Wang
  • Caifeng Zhang
  • Shilin Han
Research Article

Abstract

More and more evidence has demonstrated that astrocyte elevated gene-1 (AEG-1) is tightly associated with progression, metastasis, and unfavorable prognosis in many malignancies. However, the potential biological role of AEG-1 in gastric carcinoma (GC) has not been thoroughly delineated. In the current study, we found that AEG-1 mRNA and protein levels in GC tissues were significantly higher than those in normal gastric mucosa (P < 0.05). Simultaneously, statistical analysis displayed a significant correlation of high AEG-1 mRNA and protein expressions with differentiation status, TNM staging, invasive depth, and lymph node metastasis (P < 0.05). Most importantly, expressions of AEG-1 mRNA and protein in high clinical staging and metastatic GC tissues were dramatically higher than those in low clinical staging and non-metastatic GC tissues (P < 0.05). Stepwise investigation confirmed that the survival time of the patients with high AEG-1 level was shorter than those with low AEG-1 level or negative AEG-1 staining. Taken altogether, our data presented herein suggest that AEG-1 may be a novel predictor for metastasis and prognosis of the patients with GC.

Keywords

Astrocyte elevated gene-1 Gastric carcinoma Prognosis Clinical staging Tumor metastasis 

Notes

Acknowledgements

This work was supported by grants from Scientific Research Fund of Xinxiang Medical University (2013QN128).

Conflicts of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2014

Authors and Affiliations

  • Liangpeng Dong
    • 1
  • Shuang Qin
    • 1
  • Yan Li
    • 1
  • Lunde Zhao
    • 1
  • Shuping Dong
    • 2
  • Ying Wang
    • 3
  • Caifeng Zhang
    • 2
  • Shilin Han
    • 4
  1. 1.Department of General Surgerythe First Affiliated Hospital of Xinxiang Medical UniversityWeihuiChina
  2. 2.Department of Gastroenterologythe First Affiliated Hospital of Xinxiang Medical UniversityWeihuiPeople’s Republic of China
  3. 3.Department of Oncologythe First Affiliated Hospital of Xinxiang Medical UniversityWeihuiChina
  4. 4.Basic Medical CollegeXinxiang Medical UniversityXinxiangChina

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