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Tumor Biology

, Volume 36, Issue 3, pp 2155–2161 | Cite as

DNA repair gene polymorphisms in B cell non-Hodgkin’s lymphoma

  • Aykut Bahceci
  • Semra Paydas
  • Kahraman Tanriverdi
  • Melek Ergin
  • Gulsah Seydaoglu
  • Gulsum Ucar
Research Article

Abstract

Cancer is a group of diseases characterized by DNA injury, and genetic and environmental factors are important in the etiology of the cancers. It is well known that there are association variabilities in DNA repairment and sensitivity against the cancer. The aim of this study is to look for some important gene polymorphisms associated with DNA repair in cases with B cell non-Hodgkin’s lymphoma (B-NHL). Ninety-four cases with NHL and 96 healthy controls were included in this study. ERCC2 (Lys751Gln), XPC (Gln939Lys), ERCC5 (Asp1104His), and XRCC3 (Thr241Met) gene polymorphisms were studied by using Tm Shift Real-Time PCR Technology. ERCC5 Asp1104His polymorphism showed a protective effect against the B-NHL in individuals carrying this mutant allele (p = 0.009), and differences were more prominent in males (p = 0.001). When the patient and control groups were divided according to their smoking habit, the mutant allele of the XPC gene showed a protective effect in the nonsmoker group (p = 0.040). The mutant allele G of ERCC5 (CG) polymorphism was found to be protective against lymphoma (p = 0.010). There were no differences among cases with B-NHL and controls for ERCC2 codon 751, XPC codon 939, and XRCC3 codon 241 gene polymorphisms. DNA repair gene polymorphisms can affect the risk of lymphoma, and it will be useful to detect the DNA repair gene polymorphisms in cases with lymphoma in studies covering a higher number of cases.

Keywords

Capacity of DNA repairment Gene polymorphism Risk Lymphoma Age 

Notes

Acknowledgments

This study has been supported by the Turkish Medical Oncology Society and Cukurova University Research Fund.

Conflicts of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2014

Authors and Affiliations

  • Aykut Bahceci
    • 1
  • Semra Paydas
    • 1
  • Kahraman Tanriverdi
    • 2
  • Melek Ergin
    • 3
  • Gulsah Seydaoglu
    • 4
  • Gulsum Ucar
    • 5
  1. 1.Department of Medical OncologyUniversity of CukurovaAdanaTurkey
  2. 2.University of Massachusetts Medical SchoolWorcesterUSA
  3. 3.Department of PathologyUniversity of CukurovaAdanaTurkey
  4. 4.Department of BiostatisticsUniversity of CukurovaAdanaTurkey
  5. 5.Department of Pediatric HematologyUniversity of CukurovaAdanaTurkey

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