Radiofrequency ablation (RFA) is one of the treatment modes for liver cancer. The trauma caused by RFA is small, and its local curative effect is reliable. Computed tomography (CT) can only be used for axial scans, and parts of the lesion are unclear on plain scans. The aim of this study is to compare the local curative effect of RFA percutaneously guided by MRI and ultrasound for small hepatocellular carcinoma (HCC). This study is a retrospective study. In this study, we examined 60 cases of 88 liver lesions and 50 cases of 52 lesions, in which RFA was guided by MRI and ultrasound, respectively. All cases were clinically diagnosed. The therapeutic effect of ablation lesions was examined by postoperative imaging follow-up. The results indicated that there were 5 (5/88) recurrences of liver lesions with MRI-guided RFA and 14 (14/52) recurrences of liver lesions with ultrasound-guided RFA. The median time to recurrence in the case of recurrent lesions was 7 months. Postoperative ablation lesions showed a low-intensity signal surrounded by a thin high-intensity signal ring on T2WI images. On T1WI images, the ablation lesion showed a concentric pattern and the central area of the original lesion continued to show a low-intensity signal with a clear ring of high-intensity signal that had a clear boundary. In conclusion, the local curative effect of MRI-guided RFA for small HCC is superior to that of ultrasound-guided RFA.
Radiofrequency ablation Small hepatocellular carcinoma Magnetic resonance imaging Ultrasound Guidance
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This study was sponsored by the Natural Science Foundation of Fujian Province, China (2012J01337); the Key Project of Fujian Province Science and Technology, China (2013Y0036); and the Medical Elite Cultivation Program of Fujian, PRC (2013-ZQN-ZD-20).
Conflicts of interest
Liu Y, Liu YW, Yan XL, Xu Y, Luo F, Ye J, et al. HIFs enhance the migratory and neoplastic capacities of hepatocellular carcinoma cells by promoting EMT. Tumor Biol. 2014;35(8):8103–14.CrossRefGoogle Scholar
Niu YH, Huang TR, Lian F, Li FH. Contrast-enhanced ultrasonography for the diagnosis of small hepatocellular carcinoma: a meta-analysis and meta-regression analysis. Tumor Biol. 2013;34(6):3667–74.CrossRefGoogle Scholar
Kim YJ, Lee MW, Park HS. Small hepatocellular carcinomas: ultrasonography-guided percutaneous radiofrequency ablation. Abdom Imaging. 2013;38(1):98–111.CrossRefPubMedGoogle Scholar
Rajesh S, Mukund A, Arora A, Jain D, Sarin SK. Contrast-enhanced US-guided radiofrequency ablation of hepatocellular carcinoma. J Vasc Interv Radiol. 2013;24(8):1235–40.CrossRefPubMedGoogle Scholar
Khankan AA, Murakami T, Onishi H, Matsushita M, Iannaccone R, Aoki Y, et al. Hepatocellular carcinoma treated with radiofrequency ablation: an early evaluation with magnetic resonance imaging. J Magn Reson Imaging. 2008;27(3):546–51.CrossRefPubMedGoogle Scholar
Sironi S, Livraghi T, Meloni F, De Cobelli F, Ferrero C, Del Maschio A. Small hepatocellular carcinoma treated with percutaneous RF ablation: MR imaging follow-up. AJR Am J Roentgenol. 1999;173(5):1225–9.CrossRefPubMedGoogle Scholar
Ma XL, Zhan WL, Zhang BL, Wei BL, Wu X, Zhou M, et al. Elastography for the differentiation of benign and malignant liver lesions: a meta-analysis. Tumor Biol. 2014;35(5):4489–97.CrossRefGoogle Scholar
Lin ZY, Chen J, Deng XF. Treatment of hepatocellular carcinoma adjacent to large blood vessels using 1.5T MRI-guided percutaneous radiofrequency ablation combined with iodine-125 radioactive seed implantation. Eur J Radiol. 2012;81(11):3079–83.CrossRefPubMedGoogle Scholar
Lu DS, Raman SS, Vodopich DJ, Wang M, Sayre J, Lassman C. Effect of vessel size on creation of hepatic radiofrequency lesions in pigs: assessment of the “heat sink” effect. Am J Roentgenol. 2002;178(1):47–51.CrossRefGoogle Scholar
Lu DS, Raman SS, Limanond P, Aziz D, Economou J, Busuttil R, et al. Influence of large peri-tumoral vessel on outcome of radiofrequency ablation of liver tumors. J Vasc Interv Radiol. 2003;14(10):1267–74.CrossRefPubMedGoogle Scholar
Jiang GS, Xu XJ, Ren ST, Wang L. Combining transarterial chemoembolization with radiofrequency ablation for hepatocellular carcinoma. Tumor Biol. 2014;35(4):3405–8.CrossRefGoogle Scholar
Lu DS, Yu NC, Raman SS, Limanond P, Lassman C, Murray K, et al. Radiofrequency ablation of hepatocellular carcinoma: treatment success as defined by histologic examination of the explanted liver. Radiology. 2005;234(3):954–60.CrossRefPubMedGoogle Scholar