Tumor Biology

, Volume 36, Issue 1, pp 41–53 | Cite as

Small nucleolar RNAs functioning and potential roles in cancer

Review

Abstract

Non-coding RNAs (ncRNAs) are important regulatory molecules involved in various physiological and pathological cellular processes. Small nucleolar RNAs (snoRNAs), subclass of small ncRNAs, have been considered important but unglamorous elements in the production of protein synthesis machinery of cells. However, recent evidence has indicated that these non-coding RNAs might have a crucial role also in controlling cell behavior, and snoRNAs dysfunction could significantly contribute to carcinogenesis. Here, we summarize the most important aspects of snoRNAs biology, their functioning in cancer cell, and potential usage in diagnosis or as a new class of therapeutic targets in cancer.

Keywords

Cancer Small nucleolar RNAs Non-coding RNAs GAS5 

Notes

Acknowledgments

This work was supported by the project “Employment of Best Young Scientists for International Cooperation Empowerment” (CZ.1.07/2.3.00/30.0037), co-financed from the European Social Fund and the state budget of the Czech Republic, by the project “CEITEC—Central European Institute of Technology” (CZ.1.05/1.1.00/02.0068) and by the project MZ CR–RVO (MOU, 00209805). The authors would like to thank Andrej Besse for preparation of the figures and John B. Smith for proofreading the manuscript.

Conflicts of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2014

Authors and Affiliations

  1. 1.Central European Institute of TechnologyMasaryk UniversityBrnoCzech Republic
  2. 2.Department of Comprehensive Cancer CareMasaryk Memorial Cancer InstituteBrnoCzech Republic

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