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Down-regulation of LATS2 in non-small cell lung cancer promoted the growth and motility of cancer cells

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Tumor Biology

Abstract

LATS2 (Large tumor suppressor) has been reported to be dys-regulated in several cancer types. However, its function in non-small cell lung cancer (NSCLC) remains poorly understood. Here, it was found that the expression level of LATS2 was decreased in NSCLC tissues. Moreover, forced expression of LATS2 in NSCLC cells inhibited cell growth and migration, while knockdown of the expression of LATS2 promoted the tumorigenicity of NSCLC cells. Mechanistically, LATS2 was found to negatively regulate NF-κB signaling in NSCLC cells. Taken together, our study suggested that down-regulation of LATS2 was very important in the progression of NSCLC, and restoring the function of LATS2 might be a promising therapeutic strategy for NSCLC.

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Acknowledgments

This work was supported by the National Natural Science Foundation of China (81201840), the Natural Science Foundation of Shanghai (13ZR1461300), the Health Bureau Foundation of Shanghai (20124Y152), and Chenxing Young Scholarship of Shanghai Jiaotong University.

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Authors and Affiliations

  1. Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University, 241 West Huaihai Rd, Shanghai, 200030, China

    Feng Yao, Zhigang Li, Chenxi Zhong & Wentao Fang

  2. Department of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, 200433, China

    Hongcheng Liu

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  1. Feng Yao
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  2. Hongcheng Liu
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  3. Zhigang Li
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  4. Chenxi Zhong
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  5. Wentao Fang
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Correspondence to Wentao Fang.

Additional information

Feng Yao and Hongcheng Liu contributed equally to this work.

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Yao, F., Liu, H., Li, Z. et al. Down-regulation of LATS2 in non-small cell lung cancer promoted the growth and motility of cancer cells. Tumor Biol. 36, 2049–2057 (2015). https://doi.org/10.1007/s13277-014-2812-1

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  • DOI: https://doi.org/10.1007/s13277-014-2812-1

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