The polymorphism MMP1 −1607 (1G>2G) is associated with a significantly increased risk of cancers from a meta-analysis
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Growing evidences show that matrix metalloproteinase 1 (MMP1) plays important roles in tumorigenesis and cancer metastasis. MMP1 −1607 1G>2G is a single nucleotide polymorphism in the promoter region of MMP1 and affects MMP1 production. Analysis of previous studies on the association of −1607 1G>2G polymorphism with different cancer types remained to be illustrated. To further assess the effect of −1607 1G>2G polymorphism on cancer risk, we performed this meta-analyses, up to September 8, 2014, of 10,640 cases and 10,915 controls from 42 published case–control designed studies. Statistical analyses were performed using STATA 11.0 software. Crude odds ratios (ORs) with 95 % confidence intervals (CIs) were used to assess the strength of associations. ORs with 95 % CIs for the polymorphism MMP1 −1607 1G>2G and cancer were estimated using fixed and random effects models when appropriate. Significantly increased risks were found in overall under the models of 2G vs.1G, 2G2G vs. 1G1G, 2G2G/1G2G vs. 1G1G, and 2G2G vs. 2G1G/1G1G. Significantly elevated risks were observed in colorectal adenoma under the models of 2G vs. 1G, 2G2G vs. 1G1G, 2G2G/1G2G vs. 1G1G, and 2G2G vs. 2G1G/1G1G and lung cancer and head and neck cancer under the models of 2G vs. 1G. We found that significantly elevated risks were observed in Asian population and hospital-based studies in most comparison models tested. Thus, this meta-analysis indicates that the polymorphism MMP1 −1607 1G>2G is significantly associated with a significantly increased risk of cancers and may provide evidence-based medical certificate to study the cancer susceptibility.
KeywordsMMP1 −1607 (1G>2G) polymorphism Cancer risk
We thank Dr. Yang Liu for her critical comments of this manuscript.
Conflicts of interest
- 3.Sand JM, Larsen L, Hogaboam C, Martinez F, Han M, Rossel LM, et al. MMP mediated degradation of type IV collagen alpha 1 and alpha 3 chains reflects basement membrane remodeling in experimental and clinical fibrosis—validation of two novel biomarker assays. PLoS ONE. 2013;8:e84934.CrossRefPubMedPubMedCentralGoogle Scholar
- 9.Chimal-Ramirez GK, Espinoza-Sanchez NA, Utrera-Barillas D, Benitez-Bribiesca L, Velazquez JR, Arriaga-Pizano LA, et al. MMP1, MMP9, and COX2 expressions in promonocytes are induced by breast cancer cells and correlate with collagen degradation, transformation-like morphological changes in MCF-10A acini, and tumor aggressiveness. Biomed Res Int. 2013;2013:279505.CrossRefPubMedPubMedCentralGoogle Scholar
- 19.Kondo S, Wakisaka N, Schell MJ, Horikawa T, Sheen TS, Sato H, et al. Epstein-Barr virus latent membrane protein 1 induces the matrix metalloproteinase-1 promoter via an Ets binding site formed by a single nucleotide polymorphism: enhanced susceptibility to nasopharyngeal carcinoma. Int J Cancer. 2005;115:368–76.CrossRefPubMedGoogle Scholar
- 25.Gao W, Sui J, Wang BQ, Ling XJ, Zhang CM, Wen SX, et al. MMP-1 (−1607) 1G/2G gene polymorphism and susceptibility to nasopharyngeal in Han population in Yunnan China. China otolaryngol head and neck surg. 2010;03:116–20.Google Scholar
- 29.Cheung WY, Zhai R, Bradbury P, Hopkins J, Kulke MH, Heist RS, et al. Single nucleotide polymorphisms in the matrix metalloproteinase gene family and the frequency and duration of gastroesophageal reflux disease influence the risk of esophageal adenocarcinoma. Int J Cancer. 2012;131:2478–86.CrossRefPubMedPubMedCentralGoogle Scholar
- 31.Zhang WQ, Lin H, Zhou YA, Wang YJ, Cheng QS. Association of MMP1-1607 (1G→2G) single nucleotide polymorphism with susceptibility to lung cancer in Northwestern Chinese population of Han nationality. Chin J Med Genet. 2006; :313–315.Google Scholar
- 32.Cheng XL. Correlation o f single nucleotide polymorphism in them atrixmetalloproteinase-1 gene promoter (−1607) 1G / 2G with risk o f lung cancer. J Shanxi Med Univ. 2007:777–779.Google Scholar
- 33.Wei WQ, Liang XQ, Wen XP. The Association of MMP-1-1607 (1G→2G) single nucleotide polymorphism with the susceptibility to non-small cell lung carcinoma in Guizhou Han nationality. J Guiyang Med Coll. 2007:267–269.Google Scholar