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Tumor Biology

, Volume 36, Issue 3, pp 1595–1601 | Cite as

Prognostic value of MGMT methylation in colorectal cancer: a meta-analysis and literature review

  • Yanliang Li
  • Zhongchuan Lyu
  • Lixin Zhao
  • Hong Cheng
  • Dongyuan Zhu
  • Yongsheng Gao
  • Xiuwan Shang
  • Huaijie Shi
Research Article

Abstract

The development of colorectal cancer (CRC) spans about 5–10 years, making early detection and prevention beneficial to the survival of CRC patients. To address inconsistencies in evidence regarding O 6-methylguanine-DNA-methyltransferase (MGMT) methylation as a potential prognostic factor in CRC, we conducted a meta-analysis to evaluate MGMT methylation in CRC patients. Fourteen studies were included in the meta-analysis after screening 120 articles. The following items were collected from each study: author, published year, country, patient gender, MGMT methylation status, and patients’ disease progression. Pooled hazard ratios and odd ratios with 95 % confidence intervals (CIs) were calculated using fixed or random effect models depending on the heterogeneity between studies. The overall survival of CRC patients was found not to be significantly associated with MGMT methylation. Further subgroup analysis showed that the frequency of MGMT methylation was significantly higher in CRC than in normal tissues (p < 0.00001). MGMT promoter in CRC patients was more frequently methylated than in adenoma patients. In addition, MGMT methylation was significantly increased in adenoma than in normal tissues (p < 0.0001). In conclusion, MGMT methylation is central to the development of cancer that involves a stepwise carcinogenesis of normal adenoma carcinoma cascade. However, MGMT methylation is not associated with the prognosis of CRC.

Keywords

MGMT Colorectal tumor Diagnosis Prognosis 

Notes

Conflicts of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  • Yanliang Li
    • 1
  • Zhongchuan Lyu
    • 2
  • Lixin Zhao
    • 3
  • Hong Cheng
    • 4
  • Dongyuan Zhu
    • 5
  • Yongsheng Gao
    • 6
  • Xiuwan Shang
    • 7
  • Huaijie Shi
    • 8
    • 9
  1. 1.Department of Gastrointestinal SurgeryShandong Provincial Cancer HospitalJinanChina
  2. 2.Department of Gastrointestinal SurgeryYantai Yuhuangding HospitalYantaiChina
  3. 3.Department of Emergency RadiologyLiaocheng People’s HospitalLiaochengChina
  4. 4.Department of AnesthesiologyJinan Central Hospital Affiliated to Shandong UniversityJinanChina
  5. 5.Department of MedicineShandong Provincial Cancer HospitalJinanChina
  6. 6.Department of PathologyShandong Provincial Cancer HospitalJinanChina
  7. 7.Second Division of General Surgery DepartmentWeihai Wendeng Central HospitalWeihaiChina
  8. 8.First Division of General Surgery DepartmentRizhao City Chinese Medicine HospitalRizhaoChina
  9. 9.Second Division of General Surgery DepartmentWeihai Wendeng Central HospitalWeihaiChina

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