MACC1 overexpression and survival in solid tumors: a meta-analysis
Metastasis associated in colon cancer-1 (MACC1) is a newly identified oncogene, and increasing evidence has suggested that its overexpression is associated with the development and progression in many tumors. Here, we perform a meta-analysis to assess the relationship between MACC1 overexpression and survival in solid tumors. Eligible studies were searched in Embase, PubMed, and Web of Science databases up to May 2014. Pooled hazard ratios (HRs) with 95 % confidence intervals (CIs) were calculated to estimate the impact of MACC1 overexpression on survival using a random-effect model. A total of 20 eligible studies dealing with various tumors were included in the analysis: 17 were dealing with overall survival (OS), 7 were with relapse-free survival (RFS), and 3 were with disease-free survival (DFS). Combined results suggested a strong link between the high MACC1 expression and the poor overall survival (HR 2.11, 95 % CI 1.59–2.80, P < 0.001). For relapse-free survival, overexpressed MACC1 was also a significant predictor, with a combined HR of 2.22 (95 % CI 1.80–2.74, P < 0.001). Data from the three studies were combined to show that MACC1 overexpression had also an unfavorable impact on disease-free survival (HR 2.94, 95 % CI 1.60–5.38, P < 0.001). Publication bias was not significant. The present meta-analysis showed that overexpression of MACC1 was significantly associated with poorer survival in solid tumors.
KeywordsMACC1 Meta-analysis Prognosis
This study was supported by grants from the National Natural Science Foundation of China (nos.81372210).
Conflicts of interest
- 18.Zhang K, Zhang Y, Zhu H, Xue N, Liu J, Shan C, Zhu Q, et al. High expression of MACC1 predicts poor prognosis in patients with osteosarcoma. Tumour Biol 2014;35:1343-50.Google Scholar
- 23.Wells G, Shea B, O’connell D, Peterson J, Welch V, Losos M, Tugwell P The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses 2000Google Scholar
- 31.Zhang K, Tian F, Zhang Y, Zhu Q, Xue N, Zhu H, Wang H, Guo X, et al. MACC1 is involved in the regulation of proliferation, colony formation, invasion ability, cell cycle distribution, apoptosis and tumorigenicity by altering Akt signaling pathway in human osteosarcoma. Tumour Biol 2014;35:2537-48.Google Scholar
- 34.Zhang K, Tian F, Zhang Y, Zhu Q, Xue N, Zhu H, et al. MACC1 is involved in the regulation of proliferation, colony formation, invasion ability, cell cycle distribution, apoptosis and tumorigenicity by altering Akt signaling pathway in human osteosarcoma. Tumour Biol. 2014;35:2537–48.CrossRefPubMedGoogle Scholar