Tumor Biology

, Volume 36, Issue 2, pp 1055–1065 | Cite as

MACC1 overexpression and survival in solid tumors: a meta-analysis

Research Article

Abstract

Metastasis associated in colon cancer-1 (MACC1) is a newly identified oncogene, and increasing evidence has suggested that its overexpression is associated with the development and progression in many tumors. Here, we perform a meta-analysis to assess the relationship between MACC1 overexpression and survival in solid tumors. Eligible studies were searched in Embase, PubMed, and Web of Science databases up to May 2014. Pooled hazard ratios (HRs) with 95 % confidence intervals (CIs) were calculated to estimate the impact of MACC1 overexpression on survival using a random-effect model. A total of 20 eligible studies dealing with various tumors were included in the analysis: 17 were dealing with overall survival (OS), 7 were with relapse-free survival (RFS), and 3 were with disease-free survival (DFS). Combined results suggested a strong link between the high MACC1 expression and the poor overall survival (HR 2.11, 95 % CI 1.59–2.80, P < 0.001). For relapse-free survival, overexpressed MACC1 was also a significant predictor, with a combined HR of 2.22 (95 % CI 1.80–2.74, P < 0.001). Data from the three studies were combined to show that MACC1 overexpression had also an unfavorable impact on disease-free survival (HR 2.94, 95 % CI 1.60–5.38, P < 0.001). Publication bias was not significant. The present meta-analysis showed that overexpression of MACC1 was significantly associated with poorer survival in solid tumors.

Keywords

MACC1 Meta-analysis Prognosis 

Notes

Acknowledgments

This study was supported by grants from the National Natural Science Foundation of China (nos.81372210).

Conflicts of interest

None

Supplementary material

13277_2014_2736_MOESM1_ESM.doc (29 kb)
ESM 1 (DOC 29 kb)

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2014

Authors and Affiliations

  1. 1.Department of Colorectal CancerZhejiang Cancer HospitalHangzhouChina

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