Tumor Biology

, Volume 36, Issue 2, pp 1129–1133 | Cite as

RETRACTED ARTICLE: Nrdp1 inhibits metastasis of colorectal cancer cells by EGFR signaling-dependent MMP7 modulation

  • Yongsheng Jiang
  • Shaochuan Sun
  • Guoqin Liu
  • Bing Yan
  • Jun Niu
Research Article

Abstract

The molecular mechanism underlying cancer invasiveness and metastasis of colorectal cancer (CRC) remains elusive. Here we reported a strong correlation of the levels of neuregulin receptor degradation protein-1 (Nrdp1) and matrix metalloproteinase-7 (MMP7) in CRC from the patients. We then used a human CRC line, Caco-2, to study the underlying molecular basis. We found that Nrdp1 inhibited the phosphorylation of ErB3, a key player in epidermal growth factor receptor (EGFR) signaling in Caco-2 cells, which is required for activation of MMP7 to promote cell invasion. Our findings thus reveal Nrdp1, EGFR signaling, and MMP7 as promising therapeutic targets for preventing the metastasis of CRC.

Keywords

Neuregulin receptor degradation protein-1 (Nrdp1) Epidermal growth factor (EGF) Colorectal cancer MMP7 

Notes

Conflicts of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2014

Authors and Affiliations

  • Yongsheng Jiang
    • 1
  • Shaochuan Sun
    • 1
  • Guoqin Liu
    • 1
  • Bing Yan
    • 1
  • Jun Niu
    • 2
  1. 1.Department of General Surgery, Jinan Central HospitalShandong UniversityJinanChina
  2. 2.Department of General Surgery, Qilu HospitalShandong UniversityJinanChina

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