Prognostic value of cyclin B in endometrial endometrioid adenocarcinoma
- 197 Downloads
Cyclins are a group of cell cycle regulatory proteins. Cyclin B acts as an activator to cyclin-dependent kinase 1 (CDK1), a protein kinase essential for G2/M phase transition. Deregulation of cyclins has been linked to a number of malignant neoplasms, but the impact on clinicopathological parameters seems to be cancer-specific. Overexpression of cyclin B has been shown to affect survival in some malignant tumors, including breast and esophageal cancer, but its impact on endometrial cancer has not been extensively studied. For this study, 211 endometrial endometrioid adenocarcinoma samples were obtained from patients surgically treated at the Oulu University Hospital. The samples were immunohistochemically stained and analyzed for cyclin B expression. The relationships between cyclin B expression and conventional prognostic factors were analyzed. A discrimination threshold for survival analyses was calculated by utilizing the receiver operator characteristic (ROC) method. Cyclin B expression correlated with grade and advanced stage. Survival analyses showed that cyclin B expression affects cancer-specific survival in univariate analysis. In multivariate analysis, the results were indicative that cyclin B may hold independent prognostic significance, but further studies are required to assess this.
KeywordsCyclin B CDKs Endometrial adenocarcinoma Prognosis
Conflicts of interest
- 1.Finnish Cancer Registry. Cancer Statistics. 2012. http://www.cancer.fi/syoparekisteri/en/statistics/. Accessed: 9 May 2014.
- 17.Rijcken F, van der Zee A, van der Sluis T, Boersma-van Ek W, Kleibeuker J, Hollema H. Cell cycle regulators and apoptosis-associated proteins in relation to proliferative activity and degree of apoptosis in HNPCC versus sporadic endometrial carcinoma. Histopathology. 2006;48(3):275–85.CrossRefPubMedGoogle Scholar
- 18.Shih HC, Shiozawa T, Kato K, Imai T, Miyamoto T, et al. Immunohistochemical expression of cyclins, cyclin-dependent kinases, tumor-suppressor gene products, ki-67, and sex steroid receptors in endometrial carcinoma: positive staining for cyclin A as a poor prognostic indicator. Hum Pathol. 2003;34(5):471–8.CrossRefPubMedGoogle Scholar