Increased PTOV1 expression is related to poor prognosis in epithelial ovarian cancer
- 165 Downloads
Altered expression of prostate tumor overexpressed-1 (PTOV1) is observed in various types of human cancers. However, the role of PTOV1 in epithelial ovarian cancer (EOC) remains unclear. PTOV1 messenger (m)RNA expression in EOC patients was evaluated by quantitative real-time PCR (qRT-PCR). PTOV1 protein expression was also analyzed in archived paraffin-embedded EOC tissues using immunohistochemistry (IHC), and its association with overall survival of patients was analyzed by statistical analysis. Results from qRT-PCR analysis show that the expression level of PTOV1 mRNA was significantly higher in tumor tissues of EOC, compared to that in adjacent noncancerous tissues (P < 0.001). IHC staining showed that high expression of PTOV1 was detected in 57.2 % (87/152) of EOC cases. High expression of PTOV1 was significantly associated with pathological grade (P = 0.029) and clinical stage (P = 0.001). Moreover, the results of Kaplan-Meier analysis indicated that a high expression level of PTOV1 resulted in a significantly poor prognosis of EOC patients. Multivariate analysis showed that high expression of PTOV1 was an independent prognostic factor for overall survival (P < 0.001). In conclusion, PTOV1 protein abnormal expression might contribute to the malignant progression of EOC. High expression of PTOV1 predicts poor prognosis in patients with EOC.
KeywordsPTOV1 EOC Biomarker Prognosis
This research was supported by grant from 973 Foundation (2013CB531606).
Conflicts of interest
- 5.Tsofack SP, Meunier L, Sanchez L, Madore J, Provencher D, Mes-Masson AM, et al. Low expression of the X-linked ribosomal protein S4 in human serous epithelial ovarian cancer is associated with a poor prognosis. BMC Cancer. 2013;13:303. doi: 10.1186/1471-2407-13-303.CrossRefPubMedPubMedCentralGoogle Scholar
- 9.Santamaría A, Fernández PL, Farré X, Benedit P, Reventós J, Morote J, et al. PTOV-1, a novel protein overexpressed in prostate cancer, shuttles between the cytoplasm and the nucleus and promotes entry into the S phase of the cell division cycle. Am J Pathol. 2003;162:897–905. doi: 10.1016/S0002-9440(10)63885-0.CrossRefPubMedPubMedCentralGoogle Scholar