High c-Met expression is a negative prognostic marker for colorectal cancer: a meta-analysis
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Recent studies have shown that c-Met is an important signal in the development of colorectal cancer, but the prognostic value of c-Met remains unclear. We aimed to analyze the prognostic effect of c-Met in colorectal cancer through a systematic review and meta-analysis. Through database searches, we identified six articles describing how c-Met status affects colorectal cancer prognosis. A meta-analysis was performed to investigate the relationship between the hazard ratio and survival. The available outcome data from six articles were examined. A meta-analysis of the HR and the 95 % confidence interval (CI) indicated a significantly poor overall survival and disease-free survival in patients with high expression levels of c-Met. The subgroup analysis showed that the prognostic effect of the c-Met level was similar in different methods and was not associated with disease stages. High c-Met expression levels could predict a poor prognosis in colorectal cancer patients. The c-Met status could be used to evaluate the prognosis in clinical patients.
Keywordsc-Met Colorectal cancer Prognosis Meta-analysis
Conflicts of interest
GHL and GM contributed to the literature searching and writing of the manuscript. SZ performed the statistical analysis. BCM participated in study design and coordination and helped to draft the manuscript. All authors read and approved the final manuscript.
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