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Tumor Biology

, Volume 36, Issue 1, pp 365–369 | Cite as

Regulation of chondrosarcoma invasion by MMP26

  • Xiaoshan Xu
  • Jinxing Ma
  • Chunxiao Li
  • Wanqiu Zhao
  • Yongqing Xu
Research Article

Abstract

The molecular mechanism underlying metastasis of chondrosarcoma (CS) remains unclarified. Here, we show that matrix metalloproteinase-26 (MMP26) level is significantly higher in the resected CS than in the adjacent healthy chondral tissue from the patients. To examine the role of MMP26 in CS invasion, we used a human CS line SW1353 and we either overexpressed or inhibited MMP26 in these cells. We found that overexpression of MMP26 in SW1353 cells increased cell invasiveness, while inhibition of MMP26 decreased cell invasiveness. To define the signal transduction cascades downstream of MMP26 activation, we applied specific inhibitors for PI3K, ERK/MAPK, JNK, and Wnt signaling, respectively, to the MMP26-overexpressing SW1353 cells. We found that only inhibition of Wnt signaling by either metformin or IWP-2 significantly decreased the effect of MMP26 on cancer cell invasion, possibly through increasing β-catenin phosphorylation. Further, a strong correlation was detected between MMP26 levels and the ratio of phosphorylated/total β-catenin in CS from the patients. Taken together, our study highlights MMP26-regulated Wnt signaling as a novel therapeutic target for CS.

Keywords

Chondrosarcoma Cancer invasion MMP26 Wnt signaling 

Notes

Conflicts of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2014

Authors and Affiliations

  • Xiaoshan Xu
    • 1
  • Jinxing Ma
    • 1
  • Chunxiao Li
    • 1
  • Wanqiu Zhao
    • 1
  • Yongqing Xu
    • 1
  1. 1.Department of Orthopedic SurgeryKunming General HospitalKunmingChina

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