Tumor Biology

, Volume 36, Issue 2, pp 585–594 | Cite as

Causal relevance of circulating adiponectin with cancer: a meta-analysis implementing Mendelian randomization

  • Yuan Pei
  • Yue Xu
  • Wenquan Niu
Research Article


Some studies have observed a lower circulating level of adiponectin in cancer patients, but whether this observation is causal remains unresolved. We therefore undertook a meta-analysis implementing Mendelian randomization to exploit the causal relevance of circulating adiponectin with cancer by using multiple polymorphisms in adiponectin encoded gene ADIPOQ as instrumental variables. Eligible articles were identified from PubMed and Embase. Data and study quality were assessed in duplicate. Total 26 articles including 31 study groups were analyzed. Overall allelic association with cancer was significant for rs822396 (odds ratio (OR) = 0.91; P = 0.045) and rs1501299 (OR = 0.89; P = 0.051), with low or moderate heterogeneity. Carriers of rs2241766 GG genotype (weighted mean difference (WMD) = 0.86; P = 0.037) or G allele (WMD = 0.68; P = 0.047) had significantly higher circulating adiponectin than the TT genotype carriers, without heterogeneity. Using rs2241766 as an instrument in Mendelian randomization analysis, an increment of 1 mg/L in circulating adiponectin was significantly associated with a 43–50 % reduced risk for lung cancer, but with a 20–40 % increased risk of colorectal cancer, respectively. There was no observable publication bias. Genetically elevated circulating adiponectin might confer a protective effect against lung cancer, yet a risky effect for colorectal cancer. Further validation is urgently required.


Adiponectin Cancer Polymorphism Meta-analysis Mendelian randomization 


Conflicts of interest


Supplementary material

13277_2014_2654_MOESM1_ESM.doc (64 kb)
ESM 1 (DOC 64 kb)


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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2014

Authors and Affiliations

  1. 1.Department of Stomatology, Huashan HospitalFudan UniversityShanghaiChina
  2. 2.State Key Laboratory of Medical Genomics, Ruijin HospitalShanghai Jiaotong University School of MedicineShanghaiChina

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