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Tumor Biology

, Volume 36, Issue 2, pp 807–814 | Cite as

RETRACTED ARTICLE: Correlation of IL-1F genetic polymorphisms with the risk of colorectal cancer among Chinese populations

  • Ming Ma
  • Guo-Jiang Jin
  • Ke Yun
  • Run-Qing Mu
  • Min Zhao
  • Xiao-Ou Yu
  • Shuo Wang
  • Hong Shang
Research Article

Abstract

Inflammatory/immune cells have the power of infiltrating almost all human solid tumors and influencing all stages of carcinogenesis because of their stimulation of various cytokine subsets. This study aims to determine the correlation of single nucleotide polymorphisms in the IL-17F gene and the risk of colorectal cancer (CRC). One thousand patients diagnosed with CRC and a control group of 354 healthy controls were involved. Peripheral blood samples were collected. The PCR-RFLP method was used to detect the 7383A>G (rs2397084) and 7488T>C (rs763780) in the IL-17F gene. Statistical analyses were conducted with version 12.0 STATA statistical software. We found that the allele model suggested that patients carrying C allele were 1.67 times more likely to develop CRC than healthy controls (odds ratio (OR) = 1.67, 95 % confidence interval (CI) = 1.22–2.27, P = 0.001). Similarly, the homozygous and dominant models also revealed that the minor IL-17F 7488C allele conferred an increased CRC risk compared to the major T allele among our study participants (CC vs. TT: OR = 4.15, 95 % CI = 1.26–13.36, P = 0.011; TC+CC vs. TT: OR = 1.46, 95 % CI = 1.04–2.05, P = 0.027). However, all genetic models indicated that the IL-17F 7383A>G (rs2397084) polymorphism was not associated with CRC risk (all P > 0.05). The results of this study indicate that the 7488T>C (rs763780) in the IL-17F gene may be correlated with increased risk of CRC.

Keywords

Interleukin-17F Colorectal cancer Single nucleotide polymorphism 

Notes

Acknowledgments

We would like to acknowledge the reviewers for their helpful comments on this paper.

Conflicts of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2014

Authors and Affiliations

  • Ming Ma
    • 1
  • Guo-Jiang Jin
    • 1
  • Ke Yun
    • 1
  • Run-Qing Mu
    • 1
  • Min Zhao
    • 1
  • Xiao-Ou Yu
    • 1
  • Shuo Wang
    • 1
  • Hong Shang
    • 1
  1. 1.Department of Laboratory MedicineThe First Hospital of China Medical UniversityShenyangChina

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