Aberrant promoter hypermethylation of p16 gene in endometrial carcinoma
- 182 Downloads
Previous studies demonstrated that the loss of function of the p16INK4A gene is mainly caused by the hypermethylation of p16 gene promoter; however, whether or not it is associated with the incidence of endometrial carcinoma (EC) remains unclear. In the current study, we conducted a meta-analysis to investigate the effects of p16 gene promoter hypermethylation on the incidence of EC. Detailed research publications were searched from Embase, PubMed, and ISI Web of Knowledge for composition in English or Chinese. The pooled data were collected and analyzed by Review Manager 5.2. Odds ratios (ORs) were calculated and summarized respectively. Six eligible studies, including 261 patients were selected and analyzed. The pooled OR was 0.42, test for overall effect, Z = 10.19, P < 0.0001, indicating that p16 gene promoter hypermethylation was significantly correlated with the EC patients. The results of our study strongly suggest that p16 gene promoter hypermethylation is correlated with an increased risk of EC. P16 gene promoter hypermethylation plays a critical role in endometrial carcinogenesis.
Keywordsp16 Hypermethylation Endometrial carcinoma (EC) Therapy Meta-analysis Odds ratio
Conflicts of interest
- 40.Chao H, Sun J, Lun S. Methylation and expression of the p16 gene in endometrial carcinoma. Chin J Oncol. 2000;22:228–31.Google Scholar
- 41.Zhou L, Huang P, Zhu A. Relationships between methylation of p16 gene, Her-2 expression and serum ca125 level with clinicopathological characteristics in endometrial carcinoma. Carcinog Teratog Mutagen. 2009;21(2):33–7.Google Scholar
- 43.Formeister EJ, Tsuchiya M, Fujii H, Shpyleva S, Pogribny IP, et al. Comparative analysis of promoter methylation and gene expression endpoints between tumorous and non-tumorous tissues from HCV-positive patients with hepatocellular carcinoma. Mutat Res. 2010;692:26–33.CrossRefPubMedPubMedCentralGoogle Scholar