Tumor Biology

, Volume 36, Issue 1, pp 227–231 | Cite as

Associations between the cytotoxic T lymphocyte antigen 4 polymorphisms and risk of bone sarcomas

  • Changchun Fan
  • Xuechun Zhao
  • Zhixing Xu
Research Article


Cytotoxic T lymphocyte antigen 4 (CTLA-4) genetic polymorphisms are implicated to be associated with susceptibility to bone sarcomas, but published studies have reported inconclusive results. The objective of our study was to conduct a meta-analysis investigating the associations between CTLA-4 gene polymorphisms and risk of bone sarcomas. PubMed and Embase databases were searched for all articles published up to June 2, 2013. Odds ratio (OR) with a 95 % confidence interval (95 % CI) was used to assess the association. Finally, 11 individual studies with a total of 2,951 cases with bone sarcomas and 3,396 controls were included in the meta-analysis. There were four studies on the CTLA-4 49G/A polymorphism, three studies on CTLA-4 318C/T polymorphism, two studies on CTLA-4 1661A/G polymorphism, and two studies on CTLA-4 60A/G polymorphism. Overall, CTLA-4 49G/A polymorphism was obviously associated with risk of bone sarcomas (A vs. G: OR = 1.36, 95 % CI = 1.20–1.54; AA vs. GG: OR = 2.24, 95 % CI = 1.67–2.99; AA vs. AG/GG: OR = 2.00, 95 % CI = 1.53–2.62; AA/GA vs. GG: OR = 1.35, 95 % CI = 1.14–1.61). However, CTLA-4 318C/T, 1661A/G, and 60A/G polymorphisms were not associated with risk of bone sarcomas. The current meta-analysis suggests that CTLA-4 49G/A polymorphism is obviously associated with risk of bone sarcomas. More studies are needed to further evaluate the associations between CTLA-4 polymorphisms and risk of bone sarcomas.


CTLA-4 Bone sarcomas Polymorphism Meta-analysis 


Conflicts of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2014

Authors and Affiliations

  1. 1.Department of Orthopaedic SurgeryGeneral Hospital of Jinan Military CommandJinanChina
  2. 2.Department of Orthopaedic Surgerythe Third Hospital of Jinan CityJinanChina
  3. 3.Department of Orthopaedic SurgeryNo. 3 People’s Hospital Affiliated to Shang Hai Jiao Tong University School of MedicineShanghaiChina

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