Tumor Biology

, Volume 35, Issue 12, pp 12737–12742 | Cite as

LAPTM4B-35 protein as a potential therapeutic target in gastric cancer

  • Hongying Zhang
  • Buxian Tian
  • Hongyu Yu
  • Hongyue Yao
  • Zhian Gao
Research Article


The objective of this study is to investigate lysosome-associated protein transmembrane 4b-35 (LAPTM4B-35) protein expression in gastric cancer and its clinical implications. LAPTM4B-35 protein expression in 652 gastric cancer specimens and matched adjacent non-cancerous tissues was evaluated by immunohistochemical staining. Subsequently, the relationship between LAPTM4B-35 protein expression, clinical pathological parameters, and prognosis of gastric cancer was determined. LAPTM4B-35 protein expression was significantly higher in gastric cancer tissue compared to adjacent non-cancerous tissues (P = 0.001). In total, 417 (63.96 %) of the 652 gastric cancer cases demonstrated high LAPTM4B-35 protein expression. Multiple regression analysis was performed to identify the factors related to lymph node metastasis. As a result, age, tumor number, primary tumor category, histological type, histological growth pattern, and LAPTM4B-35 protein expression were found to be significantly related to lymph node metastasis (P = 0.010, 0.001, 0.032, 0.001, 0.001, and 0.001, respectively). Survival analysis identified that LAPTM4B-35 protein expression was also an independent prognostic factor (P = 0.001). LAPTM4B-35 was highly expressed in gastric cancer and may be a potential target for the management of gastric cancer.


Gastric cancer LAPTM4B-35 Lymph node Metastasis Prognosis 


Conflicts of interest



  1. 1.
    Catalano V, Labianca R, Beretta GD, Gatta G, de Braud F, Van Cutsem E. Gastric cancer. Crit Rev Oncol Hematol. 2009;71(2):127–64.PubMedCrossRefGoogle Scholar
  2. 2.
    Penon D, Cito L, Giordano A. Novel findings about management of gastric cancer: a summary from 10th IGCC. World J Gastroenterol. 2014;20(27):8986–92.PubMedCentralPubMedGoogle Scholar
  3. 3.
    Zhou L, He XD, Chen J, Cui QC, Qu Q, Rui JA, et al. Overexpression of LAPTM4B-35 closely correlated with clinicopathological features and post-resectional survival of gallbladder carcinoma. Eur J Cancer. 2007;43(4):809–15.PubMedCrossRefGoogle Scholar
  4. 4.
    Zhang H, Wei Q, Liu R, Qi S, Liang P, Qi C, et al. Overexpression of LAPTM4B-35: a novel marker of poor prognosis of prostate cancer. PLoS One. 2014;9(3):e91069.PubMedCentralPubMedCrossRefGoogle Scholar
  5. 5.
    Sobin LH, Wittekind CH. TNM classification of malignant tumors. 5th ed. New York: Wiley; 1997.Google Scholar
  6. 6.
    Nashimoto A, Akazawa K, Isobe Y, Miyashiro I, Katai H, Kodera Y, et al. Gastric cancer treated in 2002 in Japan: 2009 annual report of the JGCA nationwide registry. Gastric Cancer. 2013;16(1):1–27.PubMedCentralPubMedCrossRefGoogle Scholar
  7. 7.
    Fujimori Y, Inokuchi M, Takagi Y, Kato K, Kojima K, Sugihara K. Prognostic value of RKIP and p-ERK in gastric cancer. J Exp Clin Cancer Res. 2012;31:30.PubMedCentralPubMedCrossRefGoogle Scholar
  8. 8.
    Wu HH, Lin WC, Tsai KW. Advances in molecular biomarkers for gastric cancer: miRNAs as emerging novel cancer markers. Expert Rev Mol Med. 2014;16:e1.PubMedCentralPubMedCrossRefGoogle Scholar
  9. 9.
    Yang H, Zhai G, Ji X, Xiong F, Su J, McNutt MA. LAPTM4B allele *2 is a marker of poor prognosis following hepatic tumor resection for hepatocellular carcinoma. PLoS One. 2012;7(4):e34984.PubMedCentralPubMedCrossRefGoogle Scholar
  10. 10.
    Xu Y, Liu Y, Zhou R, Meng F, Gao Y, Yang S, et al. LAPTM4B polymorphisms is associated with ovarian cancer susceptibility and its prognosis. Jpn J Clin Oncol. 2012;42(5):413–9.PubMedCrossRefGoogle Scholar
  11. 11.
    Kang Y, Yin M, Jiang W, Zhang H, Xia B, Xue Y, et al. Overexpression of LAPTM4B-35 is associated with poor prognosis in colorectal carcinoma. Am J Surg. 2012;204(5):677–83.PubMedCrossRefGoogle Scholar
  12. 12.
    Huang L, Zhou K, Yang Y, Shang Z, Wang J, Wang D, et al. FLT3-ITD-associated gene-expression signatures in NPM1-mutated cytogenetically normal acute myeloid leukemia. Int J Hematol. 2012;96(2):234–40.PubMedCrossRefGoogle Scholar
  13. 13.
    Zhang G, Liang Y, Huang Y, Chen Y, Zhou R. Elevated lysosome-associated protein transmembrane-4β-35 is an independent prognostic marker in pancreatic carcinoma. J Int Med Res. 2012;40(4):1275–83.PubMedCrossRefGoogle Scholar

Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2014

Authors and Affiliations

  • Hongying Zhang
    • 1
  • Buxian Tian
    • 1
  • Hongyu Yu
    • 1
  • Hongyue Yao
    • 1
  • Zhian Gao
    • 1
    • 2
  1. 1.Department of PathologyThe First Affiliated Hospital of Liaoning Medical UniversityJingzhouPeople’s Republic of China
  2. 2.Department of Thoracic SurgeryThe First Affiliated Hospital of Liaoning Medical UniversityJingzhouPeople’s Republic of China

Personalised recommendations