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Tumor Biology

, Volume 35, Issue 12, pp 12555–12559 | Cite as

Mitochondrial DNA haplogroup N is associated good outcome of gastric cancer

  • Cuiju Wang
  • Yingnan Wang
  • Huiying Wang
  • Ruixing Zhang
  • Zhanjun Guo
Research Article

Abstract

Accumulation of mutations and single nucleotide polymorphisms (SNPs) in the displacement loop (D-loop) of mitochondrial DNA (mtDNA) has been identified for their association with cancer risk and disease outcome in a variety of cancers. We have identified cancer risk-associated D-loop SNPs in gastric cancer patients. In this study, we evaluated the predictive value of these SNPs for cancer outcome. Two SNP sites of nucleotides 489C/T and 523–524AC/del were identified for statistically significant prediction of postoperative survival in gastric cancer by univariate analysis with log-rank test. In addition, the mitochondrial DNA haplogroup N (489T) contributed to the good survival of gastric cancer patients compared with the mitochondrial DNA haplogroup M (489C) genotype (relative risk, 1.753; 95 %CI, 1.005–3.060; p = 0.048) by multivariate analysis with COX hazards model. In conclusion, analysis of genetic polymorphisms in the mitochondrial D-loop can help identify subgroups of patients who are at a high risk of a poor disease outcome.

Keywords

SNPs D-loop mtDNA Gastric cancer Outcome 

Notes

Acknowledgments

This work was supported by Key Basic Research Program of Hebei (14967713D).

Conflicts of interest

All authors disclose any financial, consulting, and personal relationships with other people or organizations that could influence their work.

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2014

Authors and Affiliations

  • Cuiju Wang
    • 1
  • Yingnan Wang
    • 2
  • Huiying Wang
    • 2
  • Ruixing Zhang
    • 2
  • Zhanjun Guo
    • 2
  1. 1.Department of Gynaecology UltrasoundThe Fourth Hospital of Hebei Medical UniversityShijiazhuangPeople’s Republic of China
  2. 2.Department of Gastroenterology and HepatologyThe Fourth Hospital of Hebei Medical UniversityShijiazhuangPeople’s Republic of China

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