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Tumor Biology

, Volume 35, Issue 12, pp 12299–12304 | Cite as

Upregulation of miR-132 expression in glioma and its clinical significance

  • Qiang Liu
  • Fan Liao
  • Hao Wu
  • Tao Cai
  • Liang Yang
  • Zhi-fei Wang
  • Ran Zou
Research Article

Abstract

miR-132 was found to be overexpressed in glioma; however, its clinical significance has not been investigated. In the present study, we evaluated the association between miR-132 and clinicopathological parameters and prognosis. Quantitative real-time PCR was used to analyze the expression of miR-132 in 113 cases of glioma and 36 cases of normal brain tissues. The association of miR-132 expression with clinicopathological factors and prognosis of glioma patients were analyzed. The expression levels of miR-132 were significantly higher in glioma tissues than that in normal brain tissues (mean ± SD, 4.448 ± 1.857 vs. 1.936 ± 0.543; P < 0.001). The miR-132 expression level was classified as high or low in relation to the median value. High expression of miR-132 was found to significantly correlate with KPS score (P = 0.001); extent of resection (P = 0.009), and WHO grade (P < 0.001). Kaplan–Meier analysis with the log-rank test indicated that high miR-132 expression had a significant impact on overall survival (17.3 vs. 56.2 %; P = 0.04) and progression-free survival (11.7 vs. 50.5 %; P = 0.012). In conclusion, this study identified high miR-132 expression as a biomarker of poor prognosis in patients diagnosed with glioma.

Keywords

miR-132 Glioma Prognosis Biomarker 

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2014

Authors and Affiliations

  • Qiang Liu
    • 1
  • Fan Liao
    • 1
  • Hao Wu
    • 1
  • Tao Cai
    • 1
  • Liang Yang
    • 1
  • Zhi-fei Wang
    • 1
  • Ran Zou
    • 2
  1. 1.Department of NeurosurgeryThe Third Xiangya Hospital, Central South UniversityChangshaChina
  2. 2.Hospice Care CenterThe Tumor Hospital of Hunan ProvinceChangshaChina

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